kdsA protein (Pseudomonas aeruginosa) - STRING interaction network

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kdsA

2-dehydro-3-deoxyphosphooctonate aldolase; KDO8P_synth- 3-deoxy-8-phosphooctulonate synthase; Belongs to the KdsA family (281 aa)

Predicted Functional Partners:

kdsD

0.999

DR97_1637

0.996

kdsB

0.988

lpxK

0.969

lpxB

0.957

pyrG

0.951

lpxC

0.950

lpxA

0.949

lpxD

0.934

waaA

0.894

Your Current Organism:

Pseudomonas aeruginosa

NCBI taxonomy Id: 287
Other names: ATCC 10145, ATCC 10145-U, Bacillus aeruginosus, Bacillus pyocyaneus, Bacterium aeruginosum, Bacterium pyocyaneum, CCEB 481, CCUG 28447, CCUG 29297, CCUG 551, CFBP 2466, CIP 100720, DSM 50071, IBCS 277, IFO 12689, JCM 5962, Micrococcus pyocyaneus, NBRC 12689, NCCB 76039, NCIB 8295, NCIMB 8295, NCTC 10332, NRRL B-771, P. aeruginosa, Pseudomonas aeruginosa, Pseudomonas polycolor, Pseudomonas pyocyanea, Pseudomonas sp. RV3, RH 815, VKM B-588, bacterium ASFP-37, bacterium ASFP-38, bacterium ASFP-45, bacterium ASFP-46, bacterium ASFP-48

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DR97_1637	kdsA	DR97_1637	DR97_4303	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC; Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family	2-dehydro-3-deoxyphosphooctonate aldolase; KDO8P_synth- 3-deoxy-8-phosphooctulonate synthase; Belongs to the KdsA family	0.996
DR97_1637	kdsB	DR97_1637	DR97_4960	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC; Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family	3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	0.994
DR97_1637	kdsD	DR97_1637	DR97_1636	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC; Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family	Arabinose 5-phosphate isomerase; kpsF- sugar isomerase, KpsF/GutQ family protein	0.997
DR97_1637	lpxA	DR97_1637	DR97_4295	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC; Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family	Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	0.689
DR97_1637	lpxB	DR97_1637	DR97_4296	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC; Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family	Lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	0.662
DR97_1637	lpxC	DR97_1637	DR97_1584	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC; Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family	UDP-3-O-acyl-N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family	0.659
DR97_1637	lpxD	DR97_1637	DR97_4293	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC; Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family	UDP-3-O-acylglucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell; Belongs to the transferase hexapeptide repeat family. LpxD subfamily	0.686
DR97_1637	lpxK	DR97_1637	DR97_4958	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC; Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family	Tetraacyldisaccharide 4’-kinase; Transfers the gamma-phosphate of ATP to the 4’-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4’-bis-phosphate (lipid IVA)	0.578
DR97_1637	waaA	DR97_1637	DR97_2342	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC; Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family	annotation not available	0.597
kdsA	DR97_1637	DR97_4303	DR97_1637	2-dehydro-3-deoxyphosphooctonate aldolase; KDO8P_synth- 3-deoxy-8-phosphooctulonate synthase; Belongs to the KdsA family	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC; Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family	0.996
kdsA	kdsB	DR97_4303	DR97_4960	2-dehydro-3-deoxyphosphooctonate aldolase; KDO8P_synth- 3-deoxy-8-phosphooctulonate synthase; Belongs to the KdsA family	3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	0.988
kdsA	kdsD	DR97_4303	DR97_1636	2-dehydro-3-deoxyphosphooctonate aldolase; KDO8P_synth- 3-deoxy-8-phosphooctulonate synthase; Belongs to the KdsA family	Arabinose 5-phosphate isomerase; kpsF- sugar isomerase, KpsF/GutQ family protein	0.999
kdsA	lpxA	DR97_4303	DR97_4295	2-dehydro-3-deoxyphosphooctonate aldolase; KDO8P_synth- 3-deoxy-8-phosphooctulonate synthase; Belongs to the KdsA family	Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	0.949
kdsA	lpxB	DR97_4303	DR97_4296	2-dehydro-3-deoxyphosphooctonate aldolase; KDO8P_synth- 3-deoxy-8-phosphooctulonate synthase; Belongs to the KdsA family	Lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	0.957
kdsA	lpxC	DR97_4303	DR97_1584	2-dehydro-3-deoxyphosphooctonate aldolase; KDO8P_synth- 3-deoxy-8-phosphooctulonate synthase; Belongs to the KdsA family	UDP-3-O-acyl-N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family	0.950
kdsA	lpxD	DR97_4303	DR97_4293	2-dehydro-3-deoxyphosphooctonate aldolase; KDO8P_synth- 3-deoxy-8-phosphooctulonate synthase; Belongs to the KdsA family	UDP-3-O-acylglucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell; Belongs to the transferase hexapeptide repeat family. LpxD subfamily	0.934
kdsA	lpxK	DR97_4303	DR97_4958	2-dehydro-3-deoxyphosphooctonate aldolase; KDO8P_synth- 3-deoxy-8-phosphooctulonate synthase; Belongs to the KdsA family	Tetraacyldisaccharide 4’-kinase; Transfers the gamma-phosphate of ATP to the 4’-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4’-bis-phosphate (lipid IVA)	0.969
kdsA	pyrG	DR97_4303	DR97_4302	2-dehydro-3-deoxyphosphooctonate aldolase; KDO8P_synth- 3-deoxy-8-phosphooctulonate synthase; Belongs to the KdsA family	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	0.951
kdsA	waaA	DR97_4303	DR97_2342	2-dehydro-3-deoxyphosphooctonate aldolase; KDO8P_synth- 3-deoxy-8-phosphooctulonate synthase; Belongs to the KdsA family	annotation not available	0.894
kdsB	DR97_1637	DR97_4960	DR97_1637	3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC; Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family	0.994

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