node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
dgt | surE | DR97_810 | DR97_4314 | Deoxyguanosinetriphosphate triphosphohydrolase; dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs | Stationary phase survival protein; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates | 0.973 |
dut | guaB | DR97_2692 | DR97_4100 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | 0.579 |
dut | surE | DR97_2692 | DR97_4314 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA | Stationary phase survival protein; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates | 0.934 |
dut | tmk | DR97_2692 | DR97_4977 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis | 0.995 |
guaA | guaB | DR97_4101 | DR97_4100 | Bifunctional gmp synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | 0.999 |
guaA | pyrH | DR97_4101 | DR97_4285 | Bifunctional gmp synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP | 0.813 |
guaA | pyrR | DR97_4101 | DR97_3371 | Bifunctional gmp synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP | Pyrimidine operon attenuation protein / uracil phosphoribosyltransferase; Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines | 0.660 |
guaA | surE | DR97_4101 | DR97_4314 | Bifunctional gmp synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP | Stationary phase survival protein; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates | 0.942 |
guaA | tmk | DR97_4101 | DR97_4977 | Bifunctional gmp synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis | 0.457 |
guaA | truD | DR97_4101 | DR97_4313 | Bifunctional gmp synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP | Trna pseudouridine synthase, trud family protein; Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs | 0.484 |
guaA | upp | DR97_4101 | DR97_1955 | Bifunctional gmp synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate | 0.670 |
guaB | dut | DR97_4100 | DR97_2692 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA | 0.579 |
guaB | guaA | DR97_4100 | DR97_4101 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | Bifunctional gmp synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP | 0.999 |
guaB | pyrH | DR97_4100 | DR97_4285 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP | 0.781 |
guaB | pyrR | DR97_4100 | DR97_3371 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | Pyrimidine operon attenuation protein / uracil phosphoribosyltransferase; Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines | 0.542 |
guaB | surE | DR97_4100 | DR97_4314 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | Stationary phase survival protein; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates | 0.937 |
guaB | tmk | DR97_4100 | DR97_4977 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis | 0.775 |
pcm | surE | DR97_4315 | DR97_4314 | Protein-l-isoaspartate(d-aspartate) o-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins (By similarity) | Stationary phase survival protein; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates | 0.993 |
pcm | truD | DR97_4315 | DR97_4313 | Protein-l-isoaspartate(d-aspartate) o-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins (By similarity) | Trna pseudouridine synthase, trud family protein; Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs | 0.843 |
pyrH | guaA | DR97_4285 | DR97_4101 | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP | Bifunctional gmp synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP | 0.813 |