STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
OpmEouter_NodT: efflux transporter, outer membrane factor (OMF) lipo, NodT family protein (491 aa)    
Predicted Functional Partners:
MexE
Membrane fusion protein, gold/copper resistance efflux system; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
 
 0.987
MexF
2A0602: RND transporter, hydrophobe/amphiphile efflux-1 family protein
 0.981
macB
Macrolide transport system atp-binding/permease protein; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides
 
 0.911
AmrB
2A0602: RND transporter, hydrophobe/amphiphile efflux-1 family protein
 0.856
mexE
Membrane fusion protein, multidrug efflux system; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
 
 0.851
mexC
Membrane fusion protein, multidrug efflux system; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
 
 0.850
mexA
Membrane fusion protein, multidrug efflux system; The periplasmic linker component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Required for assembly of the MexA/MexB/OprM complex. Implicated in the secretion of the siderophore pyoverdine
 
 0.839
mexF
2A0602: RND transporter, hydrophobe/amphiphile efflux-1 family protein
 0.833
DR97_5828
Membrane fusion protein, multidrug efflux system; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
 
 0.833
mexB
Multidrug resistance protein mexb; The inner membrane transporter component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Implicated in the secretion of the siderophore pyoverdine
 0.826
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 287
Other names: ATCC 10145, ATCC 10145-U, Bacillus aeruginosus, Bacillus pyocyaneus, Bacterium aeruginosum, Bacterium pyocyaneum, CCEB 481, CCUG 28447, CCUG 29297, CCUG 551, CFBP 2466, CIP 100720, DSM 50071, IBCS 277, IFO 12689, JCM 5962, Micrococcus pyocyaneus, NBRC 12689, NCCB 76039, NCIB 8295, NCIMB 8295, NCTC 10332, NRRL B-771, P. aeruginosa, Pseudomonas polycolor, Pseudomonas pyocyanea, Pseudomonas sp. RV3, RH 815, VKM B-588, bacterium ASFP-37, bacterium ASFP-38, bacterium ASFP-45, bacterium ASFP-46, bacterium ASFP-48
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