STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurence
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[Homology]
Score
FabH-23-Oxoacyl-[acyl-carrier-(ACP)] synthase III family protein; Catalyzes the condensation of octanoyl-CoA, obtained from exogenously supplied fatty acids via beta-oxidation, with malonyl- [acyl-carrier protein], forming 3-oxodecanoyl-[acyl-carrier protein], an intermediate of the fatty acid elongation cycle that can then be extended to supply all of the cellular fatty acid needs. The enzyme thereby shunts fatty acid degradation intermediates from the beta- oxidation pathway into de novo fatty acid biosynthesis (373 aa)    
Predicted Functional Partners:
DR97_4644
Rna polymerase sigma-70 factor, ecf subfamily; Belongs to the sigma-70 factor family. ECF subfamily
      0.926
DR97_4645
annotation not available
       0.855
DR97_3055
3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl synthase, N-terminal domain protein
  
  
 0.808
fabY
Acetoacetyl-[acyl-carrier protein] synthase; Involved in the initiation of the fatty acid biosynthesis. Catalyzes the condensation of acetyl coenzyme A (acetyl-CoA) with malonyl-acyl carrier protein (ACP) to make the fatty acid synthesis (FAS) primer beta-acetoacetyl-ACP. It can also use short-chain acyl-CoA as substrates, including butyryl-CoA, and hexanoyl-CoA, but does not use any of the longer chain acyl-CoA substrates
  
  
 0.803
plsX
Fatty acid/phospholipid synthesis protein plsx; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
  
  
 0.739
DR97_4593
annotation not available
  
  
 0.722
fabD
Malonyl-coa-[acyl-carrier-protein] transacylase; fabD: malonyl CoA-acyl carrier protein transacylase
  
 0.607
fabB
3-oxoacyl-[acyl-carrier-protein] synthase I; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family
 
  
 0.602
DR97_4803
annotation not available
 
     0.580
fabF2
Beta-ketoacyl-acyl-carrier-protein synthase ii; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
 
  
 0.553
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 287
Other names: ATCC 10145, ATCC 10145-U, Bacillus aeruginosus, Bacillus pyocyaneus, Bacterium aeruginosum, Bacterium pyocyaneum, CCEB 481, CCUG 28447, CCUG 29297, CCUG 551, CFBP 2466, CIP 100720, DSM 50071, IBCS 277, IFO 12689, JCM 5962, Micrococcus pyocyaneus, NBRC 12689, NCCB 76039, NCIB 8295, NCIMB 8295, NCTC 10332, NRRL B-771, P. aeruginosa, Pseudomonas polycolor, Pseudomonas pyocyanea, Pseudomonas sp. RV3, RH 815, VKM B-588, bacterium ASFP-37, bacterium ASFP-38, bacterium ASFP-45, bacterium ASFP-46, bacterium ASFP-48
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