node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
LolC | LolE | DR97_4951 | DR97_4953 | Hypothetical protein; lolCE: liporeleasing system, transmembrane , LolC/E family protein | lolCE: liporeleasing system, transmembrane , LolC/E family protein | 0.946 |
LolC | lolA | DR97_4951 | DR97_5348 | Hypothetical protein; lolCE: liporeleasing system, transmembrane , LolC/E family protein | Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) | 0.980 |
LolC | lolB | DR97_4951 | DR97_1977 | Hypothetical protein; lolCE: liporeleasing system, transmembrane , LolC/E family protein | Outer membrane lipoprotein lolb; Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein | 0.955 |
LolC | lolD | DR97_4951 | DR97_4952 | Hypothetical protein; lolCE: liporeleasing system, transmembrane , LolC/E family protein | Putative lipoprotein releasing system atp-binding protein; Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner | 0.994 |
LolC | macB | DR97_4951 | DR97_6042 | Hypothetical protein; lolCE: liporeleasing system, transmembrane , LolC/E family protein | Macrolide transport system atp-binding/permease protein; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides | 0.777 |
LolC | pvdR | DR97_4951 | DR97_6043 | Hypothetical protein; lolCE: liporeleasing system, transmembrane , LolC/E family protein | Membrane fusion protein, macrolide-specific efflux system; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family | 0.533 |
LolE | LolC | DR97_4953 | DR97_4951 | lolCE: liporeleasing system, transmembrane , LolC/E family protein | Hypothetical protein; lolCE: liporeleasing system, transmembrane , LolC/E family protein | 0.946 |
LolE | ftsY | DR97_4953 | DR97_3340 | lolCE: liporeleasing system, transmembrane , LolC/E family protein | Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components | 0.429 |
LolE | lolA | DR97_4953 | DR97_5348 | lolCE: liporeleasing system, transmembrane , LolC/E family protein | Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) | 0.987 |
LolE | lolB | DR97_4953 | DR97_1977 | lolCE: liporeleasing system, transmembrane , LolC/E family protein | Outer membrane lipoprotein lolb; Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein | 0.956 |
LolE | lolD | DR97_4953 | DR97_4952 | lolCE: liporeleasing system, transmembrane , LolC/E family protein | Putative lipoprotein releasing system atp-binding protein; Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner | 0.991 |
LolE | macB | DR97_4953 | DR97_6042 | lolCE: liporeleasing system, transmembrane , LolC/E family protein | Macrolide transport system atp-binding/permease protein; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides | 0.777 |
LolE | pvdR | DR97_4953 | DR97_6043 | lolCE: liporeleasing system, transmembrane , LolC/E family protein | Membrane fusion protein, macrolide-specific efflux system; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family | 0.533 |
ffh | ftsY | DR97_4130 | DR97_3340 | Signal recognition particle subunit srp54; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual co [...] | Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components | 0.998 |
ffh | ksgA | DR97_4130 | DR97_3561 | Signal recognition particle subunit srp54; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual co [...] | 16S rRNA (adenine1518-N6/adenine1519-N6)-dimethyltransferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits | 0.871 |
ffh | lolD | DR97_4130 | DR97_4952 | Signal recognition particle subunit srp54; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual co [...] | Putative lipoprotein releasing system atp-binding protein; Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner | 0.761 |
ffh | serS | DR97_4130 | DR97_5350 | Signal recognition particle subunit srp54; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual co [...] | Seryl-trna synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec) | 0.784 |
ftsY | LolE | DR97_3340 | DR97_4953 | Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components | lolCE: liporeleasing system, transmembrane , LolC/E family protein | 0.429 |
ftsY | ffh | DR97_3340 | DR97_4130 | Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components | Signal recognition particle subunit srp54; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual co [...] | 0.998 |
ftsY | ksgA | DR97_3340 | DR97_3561 | Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components | 16S rRNA (adenine1518-N6/adenine1519-N6)-dimethyltransferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits | 0.892 |