node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DR97_2966 | folE1 | DR97_2966 | DR97_4484 | Queuosine precursor transporter; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage | Gtp cyclohydrolase ia; folE: GTP cyclohydrolase I | 0.447 |
DR97_2966 | folE2 | DR97_2966 | DR97_214 | Queuosine precursor transporter; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage | Gtp cyclohydrolase ia; folE: GTP cyclohydrolase I | 0.450 |
DR97_2966 | queA | DR97_2966 | DR97_4045 | Queuosine precursor transporter; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage | S-adenosylmethionine:trna ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) | 0.635 |
DR97_2966 | queC | DR97_2966 | DR97_961 | Queuosine precursor transporter; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage | Queuosine biosynthesis protein quec; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) | 0.721 |
DR97_2966 | queD | DR97_2966 | DR97_5294 | Queuosine precursor transporter; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage | 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase; 6-carboxy-5,6,7,8-tetrahydropterin synthase; queuosine_QueD: queuosine biosynthesis protein QueD | 0.748 |
DR97_2966 | queE | DR97_2966 | DR97_962 | Queuosine precursor transporter; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage | 7-carboxy-7-deazaguanine synthase; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds | 0.779 |
DR97_2966 | queF | DR97_2966 | DR97_5137 | Queuosine precursor transporter; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage | 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) | 0.956 |
DR97_2966 | queG | DR97_2966 | DR97_2303 | Queuosine precursor transporter; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage | Putative iron-sulfur cluster-binding protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) | 0.881 |
DR97_2966 | tgt | DR97_2966 | DR97_4046 | Queuosine precursor transporter; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage | Queuine trna-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form th [...] | 0.887 |
DR97_5136 | queF | DR97_5136 | DR97_5137 | annotation not available | 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) | 0.795 |
folE1 | DR97_2966 | DR97_4484 | DR97_2966 | Gtp cyclohydrolase ia; folE: GTP cyclohydrolase I | Queuosine precursor transporter; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage | 0.447 |
folE1 | folE2 | DR97_4484 | DR97_214 | Gtp cyclohydrolase ia; folE: GTP cyclohydrolase I | Gtp cyclohydrolase ia; folE: GTP cyclohydrolase I | 0.802 |
folE1 | queA | DR97_4484 | DR97_4045 | Gtp cyclohydrolase ia; folE: GTP cyclohydrolase I | S-adenosylmethionine:trna ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) | 0.520 |
folE1 | queC | DR97_4484 | DR97_961 | Gtp cyclohydrolase ia; folE: GTP cyclohydrolase I | Queuosine biosynthesis protein quec; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) | 0.621 |
folE1 | queD | DR97_4484 | DR97_5294 | Gtp cyclohydrolase ia; folE: GTP cyclohydrolase I | 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase; 6-carboxy-5,6,7,8-tetrahydropterin synthase; queuosine_QueD: queuosine biosynthesis protein QueD | 0.983 |
folE1 | queE | DR97_4484 | DR97_962 | Gtp cyclohydrolase ia; folE: GTP cyclohydrolase I | 7-carboxy-7-deazaguanine synthase; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds | 0.664 |
folE1 | queF | DR97_4484 | DR97_5137 | Gtp cyclohydrolase ia; folE: GTP cyclohydrolase I | 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) | 0.838 |
folE1 | queG | DR97_4484 | DR97_2303 | Gtp cyclohydrolase ia; folE: GTP cyclohydrolase I | Putative iron-sulfur cluster-binding protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) | 0.894 |
folE1 | tgt | DR97_4484 | DR97_4046 | Gtp cyclohydrolase ia; folE: GTP cyclohydrolase I | Queuine trna-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form th [...] | 0.524 |
folE2 | DR97_2966 | DR97_214 | DR97_2966 | Gtp cyclohydrolase ia; folE: GTP cyclohydrolase I | Queuosine precursor transporter; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage | 0.450 |