node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |

cobA | cobG | DR97_108 | DR97_5035 | Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin | Oxidoreductase; cobG: precorrin-3B synthase | 0.863 |

cobA | cobI | DR97_108 | DR97_5037 | Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin | Methylates precorrin-2 at the C-20 position to produce precorrin-3A | 0.937 |

cobA | cobJ | DR97_108 | DR97_5038 | Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin | cobJ_cbiH: precorrin-3B C17-methyltransferase | 0.901 |

cobA | cysG | DR97_108 | DR97_5351 | Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin | Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.918 |

cobA | cysI | DR97_108 | DR97_41 | Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin | annotation not available | 0.685 |

cobA | cysN/C | DR97_108 | DR97_1620 | Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin | ATP sulfurylase may be the GTPase, regulating ATP sulfurylase activity | 0.796 |

cobA | hemC | DR97_108 | DR97_2631 | Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin | Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. | 0.941 |

cobA | hemD | DR97_108 | DR97_2630 | Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin | Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.925 |

cobA | hemE | DR97_108 | DR97_2389 | Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin | Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.921 |

cobG | cobA | DR97_5035 | DR97_108 | Oxidoreductase; cobG: precorrin-3B synthase | Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin | 0.863 |

cobG | cobI | DR97_5035 | DR97_5037 | Oxidoreductase; cobG: precorrin-3B synthase | Methylates precorrin-2 at the C-20 position to produce precorrin-3A | 0.995 |

cobG | cobJ | DR97_5035 | DR97_5038 | Oxidoreductase; cobG: precorrin-3B synthase | cobJ_cbiH: precorrin-3B C17-methyltransferase | 0.998 |

cobG | cysG | DR97_5035 | DR97_5351 | Oxidoreductase; cobG: precorrin-3B synthase | Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.920 |

cobG | cysN/C | DR97_5035 | DR97_1620 | Oxidoreductase; cobG: precorrin-3B synthase | ATP sulfurylase may be the GTPase, regulating ATP sulfurylase activity | 0.990 |

cobI | cobA | DR97_5037 | DR97_108 | Methylates precorrin-2 at the C-20 position to produce precorrin-3A | Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin | 0.937 |

cobI | cobG | DR97_5037 | DR97_5035 | Methylates precorrin-2 at the C-20 position to produce precorrin-3A | Oxidoreductase; cobG: precorrin-3B synthase | 0.995 |

cobI | cobJ | DR97_5037 | DR97_5038 | Methylates precorrin-2 at the C-20 position to produce precorrin-3A | cobJ_cbiH: precorrin-3B C17-methyltransferase | 0.999 |

cobI | cysG | DR97_5037 | DR97_5351 | Methylates precorrin-2 at the C-20 position to produce precorrin-3A | Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.963 |

cobJ | cobA | DR97_5038 | DR97_108 | cobJ_cbiH: precorrin-3B C17-methyltransferase | Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin | 0.901 |

cobJ | cobG | DR97_5038 | DR97_5035 | cobJ_cbiH: precorrin-3B C17-methyltransferase | Oxidoreductase; cobG: precorrin-3B synthase | 0.998 |