STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ccmHCytochrome c-type biogenesis protein ccmh; Required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase (By similarity) (155 aa)    
Predicted Functional Partners:
ccmI
Cytochrome c-type biogenesis protein ccmh; Required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase (By similarity)
  
 0.999
dsbE
Cytochrome c biogenesis protein ccmg, thiol:disulfide interchange protein dsbe; Involved in disulfide bond formation. Catalyzes a late, reductive step in the assembly of periplasmic c-type cytochromes, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme. Possible subunit of a heme lyase (By similarity)
 
  
 0.999
ccmF
Cytochrome c-type biogenesis protein ccmf; Required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase (By similarity)
 
 0.999
ccmE
Cytochrome c-type biogenesis protein ccme; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
 
 
 0.999
ccmC
Heme exporter ccmc family protein; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
 
  
 0.998
ccmB
Heme exporter protein ccmb; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
 
  
 0.995
ccmD
Putative heme exporter protein; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
  
  
 0.993
ccmA
Heme abc exporter, atp-binding protein ccma; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system
 
  
 0.969
dsbD1
Cytochrome c biogenesis transmembrane region family protein; Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps
      
 0.887
dsbB1
Disulfide bond formation dsbb family protein; Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
      
 0.862
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 287
Other names: ATCC 10145, ATCC 10145-U, Bacillus aeruginosus, Bacillus pyocyaneus, Bacterium aeruginosum, Bacterium pyocyaneum, CCEB 481, CCUG 28447, CCUG 29297, CCUG 551, CFBP 2466, CIP 100720, DSM 50071, IBCS 277, IFO 12689, JCM 5962, Micrococcus pyocyaneus, NBRC 12689, NCCB 76039, NCIB 8295, NCIMB 8295, NCTC 10332, NRRL B-771, P. aeruginosa, Pseudomonas polycolor, Pseudomonas pyocyanea, Pseudomonas sp. RV3, RH 815, VKM B-588, bacterium ASFP-37, bacterium ASFP-38, bacterium ASFP-45, bacterium ASFP-46, bacterium ASFP-48
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