node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
lasI | lasR | DR97_591 | DR97_592 | Acyl homoserine lactone synthase; Required for the synthesis of PAI consisting of 3-oxo-N- (tetrahydro-2-oxo-3-furanyl)-dodecanamide also known as N-(3- oxododecanoyl)homoserine lactone, an autoinducer molecule which binds to LasR and thus acts in elastase biosynthesis regulation | Luxr family transcriptional regulator, quorum-sensing system regulator lasr; Transcriptional activator of elastase structural gene (LasB). Binds to the PAI autoinducer | 0.999 |
lasI | pqsA | DR97_591 | DR97_951 | Acyl homoserine lactone synthase; Required for the synthesis of PAI consisting of 3-oxo-N- (tetrahydro-2-oxo-3-furanyl)-dodecanamide also known as N-(3- oxododecanoyl)homoserine lactone, an autoinducer molecule which binds to LasR and thus acts in elastase biosynthesis regulation | Amp-binding enzyme family protein; Catalyzes the formation of anthraniloyl-CoA, which is the priming step for entry into the Pseudomonas quinolone signal (PQS) biosynthetic pathway. Also active on a variety of aromatic substrates, including benzoate and chloro and fluoro derivatives of anthranilate | 0.854 |
lasI | pqsB | DR97_591 | DR97_950 | Acyl homoserine lactone synthase; Required for the synthesis of PAI consisting of 3-oxo-N- (tetrahydro-2-oxo-3-furanyl)-dodecanamide also known as N-(3- oxododecanoyl)homoserine lactone, an autoinducer molecule which binds to LasR and thus acts in elastase biosynthesis regulation | 2-heptyl-4(1H)-quinolone synthase subunit PqsB; Required for the biosynthesis of the quorum-sensing signaling molecules 2-heptyl-4(1H)-quinolone (HHQ) and 2-heptyl-3-hydroxy-4(1H)- quinolone (Pseudomonas quinolone signal or PQS), which are important for biofilm formation and virulence. The PqsC/PqsB complex catalyzes the condensation of 2-aminobenzoylacetate (2-ABA) and octanoyl-CoA to form HHQ. PqsB, together with PqsC, catalyzes the coupling of 2-ABA with the octanoate group, leading to decarboxylation and dehydration, and resulting in closure of the quinoline ring. PqsB is probably [...] | 0.564 |
lasI | pqsC | DR97_591 | DR97_949 | Acyl homoserine lactone synthase; Required for the synthesis of PAI consisting of 3-oxo-N- (tetrahydro-2-oxo-3-furanyl)-dodecanamide also known as N-(3- oxododecanoyl)homoserine lactone, an autoinducer molecule which binds to LasR and thus acts in elastase biosynthesis regulation | 3-Oxoacyl-[acyl-carrier-(ACP)] synthase III family protein; Required for the biosynthesis of the quorum-sensing signaling molecules 2-heptyl-4(1H)-quinolone (HHQ) and 2-heptyl-3-hydroxy-4(1H)- quinolone (Pseudomonas quinolone signal or PQS), which are important for biofilm formation and virulence. The PqsC/PqsB complex catalyzes the condensation of 2-aminobenzoylacetate (2-ABA) and octanoyl-CoA to form HHQ. First, PqsC acquires an octanoyl group from octanoyl-CoA and forms an octanoyl-PqsC intermediate. Then, together with PqsB, it catalyzes the coupling of 2-ABA with the octanoate gro [...] | 0.674 |
lasI | pqsD | DR97_591 | DR97_948 | Acyl homoserine lactone synthase; Required for the synthesis of PAI consisting of 3-oxo-N- (tetrahydro-2-oxo-3-furanyl)-dodecanamide also known as N-(3- oxododecanoyl)homoserine lactone, an autoinducer molecule which binds to LasR and thus acts in elastase biosynthesis regulation | Pqb biosynthetic 3-oxoacyl-[acyl-carrier-protein] synthase iii; Required for the biosynthesis of a number of signaling molecules, such as the quinolone signal 2-heptyl-3-hydroxy-4(1H)- quinolone (PQS), 2-heptyl-4-hydroxyquinoline (HHQ) and 2,4- dihydroxyquinoline (DHQ). These molecules are required for normal biofilm formation. Catalyzes the transfer of the anthraniloyl moiety from anthraniloyl-CoA to malonyl-CoA to form 2-aminobenzoylacetyl-CoA . The first step of the reaction is the formation of a covalent anthraniloyl-PqsD intermediate Next, the short-lived intermediate 3-(2-aminoph [...] | 0.681 |
lasI | pqsE | DR97_591 | DR97_947 | Acyl homoserine lactone synthase; Required for the synthesis of PAI consisting of 3-oxo-N- (tetrahydro-2-oxo-3-furanyl)-dodecanamide also known as N-(3- oxododecanoyl)homoserine lactone, an autoinducer molecule which binds to LasR and thus acts in elastase biosynthesis regulation | Metallo-beta-lactamase superfamily protein; Required for the biosynthesis of the quorum-sensing signaling molecules 2-heptyl-4(1H)-quinolone (HHQ) and 2-heptyl-3-hydroxy-4(1H)- quinolone (Pseudomonas quinolone signal or PQS), which are important for biofilm formation and virulence. Catalyzes the hydrolysis of the intermediate 2-aminobenzoylacetyl-CoA (2-ABA-CoA) to form 2- aminobenzoylacetate (2-ABA), the precursor of HHQ. In vitro, can also hydrolyze other substrates such as S-ethyl-acetothioacetate and acetoacetyl-CoA, but is inactive against anthraniloyl-CoA, malonyl-CoA and octanoy [...] | 0.851 |
lasI | pqsH | DR97_591 | DR97_5458 | Acyl homoserine lactone synthase; Required for the synthesis of PAI consisting of 3-oxo-N- (tetrahydro-2-oxo-3-furanyl)-dodecanamide also known as N-(3- oxododecanoyl)homoserine lactone, an autoinducer molecule which binds to LasR and thus acts in elastase biosynthesis regulation | 2-heptyl-3-hydroxy-4(1H)-quinolone synthase; Involved in the terminal step of the biosynthesis of quinolone which in addition to serve as a potent signal for quorum sensing, chelates iron and promotes the formation of membrane vesicles (MVs). Catalyzes the hydroxylation of 2-heptyl-4-quinolone (C7-HHQ) to yield 2-heptyl-3-hydroxy-4-quinolone (PQS) | 0.854 |
lasI | rhlB | DR97_591 | DR97_4005 | Acyl homoserine lactone synthase; Required for the synthesis of PAI consisting of 3-oxo-N- (tetrahydro-2-oxo-3-furanyl)-dodecanamide also known as N-(3- oxododecanoyl)homoserine lactone, an autoinducer molecule which binds to LasR and thus acts in elastase biosynthesis regulation | Atp-dependent rna helicase rhlb; DEAD-box RNA helicase involved in RNA degradation. Has RNA- dependent ATPase activity and unwinds double-stranded RNA | 0.854 |
lasI | rhlI | DR97_591 | DR97_4445 | Acyl homoserine lactone synthase; Required for the synthesis of PAI consisting of 3-oxo-N- (tetrahydro-2-oxo-3-furanyl)-dodecanamide also known as N-(3- oxododecanoyl)homoserine lactone, an autoinducer molecule which binds to LasR and thus acts in elastase biosynthesis regulation | Autoinducer synthetase family protein; Required for the synthesis of BHL (N-butanoyl-L-homoserine lactone), and HHL (N-hexanoyl-L-homoserine lactone) autoinducer molecules which bind to RhlR and thus acts in elastase biosynthesis regulation | 0.891 |
lasI | sdiA | DR97_591 | DR97_4444 | Acyl homoserine lactone synthase; Required for the synthesis of PAI consisting of 3-oxo-N- (tetrahydro-2-oxo-3-furanyl)-dodecanamide also known as N-(3- oxododecanoyl)homoserine lactone, an autoinducer molecule which binds to LasR and thus acts in elastase biosynthesis regulation | Luxr family transcriptional regulator, quorum-sensing system regulator rhlr; Necessary for transcriptional activation of the rhlAB genes encoding the rhamnosyltransferase. It also functions as a transcriptional activator of elastase structural gene (lasB). Binds to autoinducer molecules BHL (N-butanoyl-L-homoserine lactone), and HHL (N-hexanoyl-L-homoserine lactone) | 0.942 |
lasR | lasI | DR97_592 | DR97_591 | Luxr family transcriptional regulator, quorum-sensing system regulator lasr; Transcriptional activator of elastase structural gene (LasB). Binds to the PAI autoinducer | Acyl homoserine lactone synthase; Required for the synthesis of PAI consisting of 3-oxo-N- (tetrahydro-2-oxo-3-furanyl)-dodecanamide also known as N-(3- oxododecanoyl)homoserine lactone, an autoinducer molecule which binds to LasR and thus acts in elastase biosynthesis regulation | 0.999 |
lasR | pqsA | DR97_592 | DR97_951 | Luxr family transcriptional regulator, quorum-sensing system regulator lasr; Transcriptional activator of elastase structural gene (LasB). Binds to the PAI autoinducer | Amp-binding enzyme family protein; Catalyzes the formation of anthraniloyl-CoA, which is the priming step for entry into the Pseudomonas quinolone signal (PQS) biosynthetic pathway. Also active on a variety of aromatic substrates, including benzoate and chloro and fluoro derivatives of anthranilate | 0.854 |
lasR | pqsB | DR97_592 | DR97_950 | Luxr family transcriptional regulator, quorum-sensing system regulator lasr; Transcriptional activator of elastase structural gene (LasB). Binds to the PAI autoinducer | 2-heptyl-4(1H)-quinolone synthase subunit PqsB; Required for the biosynthesis of the quorum-sensing signaling molecules 2-heptyl-4(1H)-quinolone (HHQ) and 2-heptyl-3-hydroxy-4(1H)- quinolone (Pseudomonas quinolone signal or PQS), which are important for biofilm formation and virulence. The PqsC/PqsB complex catalyzes the condensation of 2-aminobenzoylacetate (2-ABA) and octanoyl-CoA to form HHQ. PqsB, together with PqsC, catalyzes the coupling of 2-ABA with the octanoate group, leading to decarboxylation and dehydration, and resulting in closure of the quinoline ring. PqsB is probably [...] | 0.739 |
lasR | pqsC | DR97_592 | DR97_949 | Luxr family transcriptional regulator, quorum-sensing system regulator lasr; Transcriptional activator of elastase structural gene (LasB). Binds to the PAI autoinducer | 3-Oxoacyl-[acyl-carrier-(ACP)] synthase III family protein; Required for the biosynthesis of the quorum-sensing signaling molecules 2-heptyl-4(1H)-quinolone (HHQ) and 2-heptyl-3-hydroxy-4(1H)- quinolone (Pseudomonas quinolone signal or PQS), which are important for biofilm formation and virulence. The PqsC/PqsB complex catalyzes the condensation of 2-aminobenzoylacetate (2-ABA) and octanoyl-CoA to form HHQ. First, PqsC acquires an octanoyl group from octanoyl-CoA and forms an octanoyl-PqsC intermediate. Then, together with PqsB, it catalyzes the coupling of 2-ABA with the octanoate gro [...] | 0.847 |
lasR | pqsD | DR97_592 | DR97_948 | Luxr family transcriptional regulator, quorum-sensing system regulator lasr; Transcriptional activator of elastase structural gene (LasB). Binds to the PAI autoinducer | Pqb biosynthetic 3-oxoacyl-[acyl-carrier-protein] synthase iii; Required for the biosynthesis of a number of signaling molecules, such as the quinolone signal 2-heptyl-3-hydroxy-4(1H)- quinolone (PQS), 2-heptyl-4-hydroxyquinoline (HHQ) and 2,4- dihydroxyquinoline (DHQ). These molecules are required for normal biofilm formation. Catalyzes the transfer of the anthraniloyl moiety from anthraniloyl-CoA to malonyl-CoA to form 2-aminobenzoylacetyl-CoA . The first step of the reaction is the formation of a covalent anthraniloyl-PqsD intermediate Next, the short-lived intermediate 3-(2-aminoph [...] | 0.844 |
lasR | pqsE | DR97_592 | DR97_947 | Luxr family transcriptional regulator, quorum-sensing system regulator lasr; Transcriptional activator of elastase structural gene (LasB). Binds to the PAI autoinducer | Metallo-beta-lactamase superfamily protein; Required for the biosynthesis of the quorum-sensing signaling molecules 2-heptyl-4(1H)-quinolone (HHQ) and 2-heptyl-3-hydroxy-4(1H)- quinolone (Pseudomonas quinolone signal or PQS), which are important for biofilm formation and virulence. Catalyzes the hydrolysis of the intermediate 2-aminobenzoylacetyl-CoA (2-ABA-CoA) to form 2- aminobenzoylacetate (2-ABA), the precursor of HHQ. In vitro, can also hydrolyze other substrates such as S-ethyl-acetothioacetate and acetoacetyl-CoA, but is inactive against anthraniloyl-CoA, malonyl-CoA and octanoy [...] | 0.854 |
lasR | pqsH | DR97_592 | DR97_5458 | Luxr family transcriptional regulator, quorum-sensing system regulator lasr; Transcriptional activator of elastase structural gene (LasB). Binds to the PAI autoinducer | 2-heptyl-3-hydroxy-4(1H)-quinolone synthase; Involved in the terminal step of the biosynthesis of quinolone which in addition to serve as a potent signal for quorum sensing, chelates iron and promotes the formation of membrane vesicles (MVs). Catalyzes the hydroxylation of 2-heptyl-4-quinolone (C7-HHQ) to yield 2-heptyl-3-hydroxy-4-quinolone (PQS) | 0.866 |
lasR | rhlB | DR97_592 | DR97_4005 | Luxr family transcriptional regulator, quorum-sensing system regulator lasr; Transcriptional activator of elastase structural gene (LasB). Binds to the PAI autoinducer | Atp-dependent rna helicase rhlb; DEAD-box RNA helicase involved in RNA degradation. Has RNA- dependent ATPase activity and unwinds double-stranded RNA | 0.868 |
lasR | rhlI | DR97_592 | DR97_4445 | Luxr family transcriptional regulator, quorum-sensing system regulator lasr; Transcriptional activator of elastase structural gene (LasB). Binds to the PAI autoinducer | Autoinducer synthetase family protein; Required for the synthesis of BHL (N-butanoyl-L-homoserine lactone), and HHL (N-hexanoyl-L-homoserine lactone) autoinducer molecules which bind to RhlR and thus acts in elastase biosynthesis regulation | 0.969 |
lasR | sdiA | DR97_592 | DR97_4444 | Luxr family transcriptional regulator, quorum-sensing system regulator lasr; Transcriptional activator of elastase structural gene (LasB). Binds to the PAI autoinducer | Luxr family transcriptional regulator, quorum-sensing system regulator rhlr; Necessary for transcriptional activation of the rhlAB genes encoding the rhamnosyltransferase. It also functions as a transcriptional activator of elastase structural gene (lasB). Binds to autoinducer molecules BHL (N-butanoyl-L-homoserine lactone), and HHL (N-hexanoyl-L-homoserine lactone) | 0.471 |