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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hmgAHomogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate (432 aa)    
Predicted Functional Partners:
DR97_5841
maiA: maleylacetoacetate isomerase
 
 
 0.999
hppD
4HPPD: 4-hydroxyphenylpyruvate dioxygenase
 
 
 0.997
fahA
Fum_ac_acetase: fumarylacetoacetase
  
 0.997
DR97_5701
Putative glutathione S-transferase; maiA: maleylacetoacetate isomerase
 
 
 0.994
DR97_3199
annotation not available
  
 
 0.984
phhA
Phe4hydrox_mono: phenylalanine-4-hydroxylase
 
  
 0.955
gtdA
Gentisate_1_2: gentisate 1,2-dioxygenase
  
   
 0.814
pobA
P-hydroxybenzoate hydroxylase; Pbenz_hydroxyl: 4-hydroxybenzoate 3-monooxygenase
  
  
 0.809
DR97_5102
annotation not available
      
 0.772
tyrR1
annotation not available
     
 0.762
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 287
Other names: ATCC 10145, ATCC 10145-U, Bacillus aeruginosus, Bacillus pyocyaneus, Bacterium aeruginosum, Bacterium pyocyaneum, CCEB 481, CCUG 28447, CCUG 29297, CCUG 551, CFBP 2466, CIP 100720, DSM 50071, IBCS 277, IFO 12689, JCM 5962, Micrococcus pyocyaneus, NBRC 12689, NCCB 76039, NCIB 8295, NCIMB 8295, NCTC 10332, NRRL B-771, P. aeruginosa, Pseudomonas aeruginosa, Pseudomonas polycolor, Pseudomonas pyocyanea, Pseudomonas sp. RV3, RH 815, VKM B-588, bacterium ASFP-37, bacterium ASFP-38, bacterium ASFP-45, bacterium ASFP-46, bacterium ASFP-48
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