STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
glnD(protein-PII) uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen fixation and metabolism. (931 aa)    
Predicted Functional Partners:
glnB
Nitrogen regulatory protein P-II; Evidence: Function of homologous gene experimentally demonstrated in an other organism; Localization: 2 : Cytoplasmic; Belongs to the P(II) protein family.
 
 
 0.981
BBta_7264
Nitrogen regulatory protein P-II precursor; Evidence: Function of strongly homologous gene; PUBMED: 8282715.
 
 
 0.972
glnE
Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...]
 
   
 0.928
glnK1
Nitrogen regulatory protein P-II; Evidence: Function of homologous gene experimentally demonstrated in an other organism; Belongs to the P(II) protein family.
 
 
 
 0.816
BBta_0293
Nitrogen regulatory protein P-II; Fragment; Evidence: Function of strongly homologous gene; Localization: 2 : Cytoplasmic; Belongs to the P(II) protein family.
 
 
 
 0.804
glnA-2
L-glutamine synthetase; Evidence: Function of homologous gene experimentally demonstrated in an other organism; Localization: 2 : Cytoplasmic.
 
   
 0.755
BBta_0878
L-glutamine synthetase; GlnA4-like; Evidence: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the glutamine synthetase family.
     
 0.705
BBta_3191
L-glutamine synthetase; Evidence: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Localization: 2 : Cytoplasmic; Belongs to the glutamine synthetase family.
     
 0.705
gltB
Glutamate synthase (NADH) large subunit; Evidence: Function of homologous gene experimentally demonstrated in an other organism; Localization: 2 : Cytoplasmic.
     
 0.646
ntrB
Signal transduction histidine kinase, nitrogen specific, NtrB; Evidence: Function of homologous gene experimentally demonstrated in an other organism; Localization: 2 : Cytoplasmic.
  
 
 
 0.615
Your Current Organism:
Bradyrhizobium sp. BTAi1
NCBI taxonomy Id: 288000
Other names: B. sp. BTAi1
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