STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ligDDNA ligase D, 3'-phosphoesterase domain; Identified by match to protein family HMM TIGR02777. (138 aa)    
Predicted Functional Partners:
dnaN
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.993
polA
DNA polymerase I, thermostable; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.985
ACI21532.1
DNA polymerase; Identified by match to protein family HMM PF00136; match to protein family HMM PF03104; match to protein family HMM TIGR00592.
   
 0.908
lepB
Signal peptidase I; Identified by match to protein family HMM PF00717; match to protein family HMM TIGR02227; Belongs to the peptidase S26 family.
    
 0.861
ACI21622.1
ATPase involved in DNA repair, putative.
   
 0.848
ACI20609.1
Type III restriction enzyme, res subunit family; Identified by match to protein family HMM PF04851.
   
 
 0.839
ACI20222.1
ADP-heptose--LPS heptosyltransferase II; Identified by match to protein family HMM PF01075; match to protein family HMM PF08645; match to protein family HMM TIGR01656; match to protein family HMM TIGR01662; match to protein family HMM TIGR02195.
   
 0.825
truD
tRNA pseudouridine synthase D; Identified by match to protein family HMM PF01142.
  
    0.791
ACI21474.1
Metallo-beta-lactamase superfamily; Identified by match to protein family HMM PF00753; match to protein family HMM PF07521.
  
 0.787
rpoA
DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
     
 0.775
Your Current Organism:
Thermodesulfovibrio yellowstonii
NCBI taxonomy Id: 289376
Other names: T. yellowstonii DSM 11347, Thermodesulfovibrio yellowstonii DSM 11347
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