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ALG2 protein (Kluyveromyces lactis) - STRING interaction network
"ALG2" - Alpha-1,3/1,6-mannosyltransferase ALG2 in Kluyveromyces lactis
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ALG2Alpha-1,3/1,6-mannosyltransferase ALG2; Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)- dolichol diphosphate (503 aa)    
Predicted Functional Partners:
ALG1
Chitobiosyldiphosphodolichol beta-mannosyltransferase; Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER (By similarity); Belongs to the glycosyltransferase group 1 family (447 aa)
     
  0.993
ALG11
GDP-Man-Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase; Required for N-linked oligosaccharide assembly. Has a role in the last step of the synthesis of the Man(5)GlcNAc(2)-PP- dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum (By similarity); Belongs to the glycosyltransferase group 1 family (570 aa)
     
  0.991
XP_455387.1
KLLA0F06776p; Similar to uniprot|P07286 Saccharomyces cerevisiae YBR243C ALG7 UDP-N-acetyl-glucosamine-1-P transferase transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation inhibited by tunicamycin (447 aa)
   
   
  0.802
MPG1
Mannose-1-phosphate guanyltransferase; Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell- size checkpoint (By similarity); Belongs to the transferase hexapeptide repeat family (361 aa)
   
 
  0.785
XP_453316.1
Phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions (254 aa)
   
 
  0.754
RFT1
Oligosaccharide translocation protein RFT1; May participate in the translocation of oligosaccharide from the cytoplasmic side to the lumenal side of the endoplasmic reticulum membrane (556 aa)
     
 
  0.750
XP_451744.1
KLLA0B04730p; Similar to uniprot|Q04632 Saccharomyces cerevisiae YML071C COG8 Component of the conserved oligomeric Golgi complex (418 aa)
     
 
  0.738
XP_451684.1
KLLA0B03377p; Highly similar to uniprot|P14020 Saccharomyces cerevisiae YPR183W DPM1 Dolichol phosphate mannose (Dol-P- Man) synthase of the ER membrane catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man required for glycosyl phosphatidylinositol membrane anchoring O mannosylation and protein glycosylation (265 aa)
   
 
  0.720
XP_454340.1
KLLA0E08669p; Similar to uniprot|P53966 Saccharomyces cerevisiae YNL029C KTR5 Putative mannosyltransferase involved in protein glycosylation member of the KRE2/MNT1 mannosyltransferase family (522 aa)
           
  0.705
XP_453560.1
KLLA0D11198p; Similar to uniprot|Q75DH5 Ashbya gossypii ABR051C ABR051Cp and weakly similar to YMR013C uniprot|P20048 Saccharomyces cerevisiae YMR013C SEC59 Membrane protein that catalyzes the CTP-mediated phosphorylation of dolichol the terminal step in dolichyl monophosphate (Dol- P) biosynthesis required for viability normal rates of lipid intermediate synthesis and protein N-glycosylation (515 aa)
     
   
  0.703
Your Current Organism:
Kluyveromyces lactis
NCBI taxonomy Id: 28985
Other names: Candida sphaerica, K. lactis, Kluyveromyces drosophilarum, Kluyveromyces lactis, Kluyveromyces lactis var. drosophilarum, Kluyveromyces lactis var. lactis, Kluyveromyces marxianus lactis, Kluyveromyces marxianus var. drosophilarum, Kluyveromyces marxianus var. lactis
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