STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PAC1Nuclear distribution protein PAC1; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. Plays a central role in positioning the mitotic spindle at the bud neck during cell division. Targets cytoplasmic dynein to microtubule plus ends, thereby promoting dynein- mediated microtubule sliding along the bud cortex and consequently the movement of the mitotic spindle to the bud neck. (439 aa)    
Predicted Functional Partners:
KLLA0_A05621g
KLLA0A05621p.
   
 0.997
KLLA0_F24354g
KLLA0F24354p; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
     
  0.900
KLLA0_F20163g
KLLA0F20163p; Belongs to the membrane-bound acyltransferase family.
     
  0.900
KLLA0_A07557g
Patatin-like phospholipase domain-containing protein; Lipid hydrolase; Belongs to the PLPL family.
     
  0.900
KLLA0_A09867g
KLLA0A09867p.
    
 0.896
KLLA0_F11099g
KLLA0F11099p.
   
 0.895
DYN2
Dynein light chain 1, cytoplasmic; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity).
    
 0.853
KLLA0_C11605g
KLLA0C11605p.
    
 0.810
KLLA0_E12387g
KLLA0E12387p.
    
 0.744
KLLA0_F10791g
KLLA0F10791p.
  
 
 0.729
Your Current Organism:
Kluyveromyces lactis
NCBI taxonomy Id: 284590
Other names: K. lactis NRRL Y-1140, Kluyveromyces lactis NRRL Y-1140
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.