STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
ICL1Isocitrate lyase; Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Acts also on 2- methylisocitrate; Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family. (542 aa)    
Predicted Functional Partners:
KLLA0_F23914g
Malate synthase; Belongs to the malate synthase family.
 
 
 0.999
KLLA0_C17314g
Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.
  
 0.969
KLLA0_F08954g
KLLA0F08954p.
  
 
 0.957
KLLA0_C02167g
KLLA0C02167p; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
  
 0.914
KLLA0_E13905g
Isocitrate lyase.
  
  
 
0.904
FBP1
Fructose-1,6-bisphosphatase.
   
  
 0.874
PCK1
Phosphoenolpyruvate carboxykinase (ATP); Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
   
  
 0.868
KLLA0_E13817g
KLLA0E13817p.
  
  
 0.855
KLLA0_A08492g
KLLA0A08492p.
  
 
 0.828
KLLA0_A02475g
KLLA0A02475p.
  
 
 0.828
Your Current Organism:
Kluyveromyces lactis
NCBI taxonomy Id: 284590
Other names: K. lactis NRRL Y-1140, Kluyveromyces lactis NRRL Y-1140
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