STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RAG5Hexokinase; Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D- fructose 6-phosphate, respectively). Has higher affinity for D-glucose. Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6- phosphate ; Belongs to the hexokinase family. (485 aa)    
Predicted Functional Partners:
GLK1
Glucokinase-1; Glukokinase specific for aldohexoses. Phosphorylates glucose and mannose, but not fructose; Belongs to the hexokinase family.
  
0.993
RAG2
Glucose-6-phosphate isomerase; Belongs to the GPI family.
   
 
 0.992
INV1
Invertase.
   
 
 0.969
PFK1
ATP-dependent 6-phosphofructokinase subunit alpha; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
   
 
 0.967
KLLA0_B12694g
KLLA0B12694p; Belongs to the phosphohexose mutase family.
   
 
 0.961
GAL10
Bifunctional protein GAL10; Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity).
   
 
 0.956
PFK2
ATP-dependent 6-phosphofructokinase subunit beta; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
   
 
 0.951
ZWF
Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity).
   
 
 0.943
KLLA0_D01573g
KLLA0D01573p.
   
 
 0.941
FBP1
Fructose-1,6-bisphosphatase.
   
 
 0.939
Your Current Organism:
Kluyveromyces lactis
NCBI taxonomy Id: 284590
Other names: K. lactis NRRL Y-1140, Kluyveromyces lactis NRRL Y-1140
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