STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LAC9Lactose regulatory protein LAC9; Positive regulatory protein, that controls induction of the lactose-galactose regulation of Kluyveromyces lactis. (865 aa)    
Predicted Functional Partners:
GAL80
Galactose/lactose metabolism regulatory protein GAL80; This protein is a negative regulator for the gene expression of the lactose/galactose metabolic genes. It seems to block activation by the transcriptional activator LAC9 in the absence of an inducing sugar.
   
 
 0.998
LAC4
Beta-galactosidase.
   
  
 0.763
GAL1
Galactokinase; Seems bifunctional with both a galactokinase activity and the ability to induce the GAL genes; Belongs to the GHMP kinase family. GalK subfamily.
   
 
 0.697
GAL10
Bifunctional protein GAL10; Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity).
   
 
 0.681
KLLA0_E10099g
KLLA0E10099p.
    
 
 0.602
LAC12
Lactose permease; LAC12 mediates the transport of lactose and it would appear that the permease works in part by a proton symport mechanism; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
      
 0.555
GAL7
Galactose-1-phosphate uridylyltransferase; Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
   
 
 0.545
SSN3
Serine/threonine-protein kinase SSN3; Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).
   
 
 0.543
KLLA0_E18129g
KLLA0E18129p.
      
 0.422
HIS3
Imidazoleglycerol-phosphate dehydratase; Belongs to the imidazoleglycerol-phosphate dehydratase family.
      
 0.420
Your Current Organism:
Kluyveromyces lactis
NCBI taxonomy Id: 284590
Other names: K. lactis NRRL Y-1140, Kluyveromyces lactis NRRL Y-1140
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