STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GLR1Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. (484 aa)    
Predicted Functional Partners:
KLLA0_F07557g
Glutathione synthetase.
    
 0.959
KLLA0_E20285g
KLLA0E20285p.
   
 0.938
KLLA0_F09603g
Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
  
 0.933
KLLA0_A00264g
KLLA0A00264p; Belongs to the GST superfamily.
   
 
 0.918
URE2
Protein URE2; Plays an important role in the cellular response to the nitrogen source. URE2 gene plays a major part in the repression of GLN1 and GDH2 genes by glutamine, and is required for the inactivation of glutamine synthetase. URE2 gene product may catalytically inactivate GLN3 in response to an increase in the intracellular concentration of glutamine (By similarity); Belongs to the GST superfamily.
   
 
 0.914
KLLA0_F23012g
KLLA0F23012p.
     
 0.913
KLLA0_C05236g
KLLA0C05236p.
     
 0.913
KLLA0_F10351g
Thioredoxin; Belongs to the thioredoxin family.
  
 0.902
KLLA0_C11649g
Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.
     
  0.900
TRR1
Thioredoxin reductase, mitochondrial.
  
 0.879
Your Current Organism:
Kluyveromyces lactis
NCBI taxonomy Id: 284590
Other names: K. lactis NRRL Y-1140, Kluyveromyces lactis NRRL Y-1140
Server load: low (28%) [HD]