STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CLF1Pre-mRNA-splicing factor CLF1; Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication (By similarity). (684 aa)    
Predicted Functional Partners:
SLT11
Pre-mRNA-splicing factor SLT11; Involved in pre-mRNA splicing. Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA (By similarity).
   
 0.999
ISY1
Pre-mRNA-splicing factor ISY1; Involved in pre-mRNA splicing.
   
 0.999
PRP45
Pre-mRNA-processing protein 45; Involved in pre-mRNA splicing.
  
 0.999
SYF2
Pre-mRNA-splicing factor SYF2; Involved in pre-mRNA splicing.
   
 0.999
KLLA0_C08800g
KLLA0C08800p.
    
 0.999
SYF1
Pre-mRNA-splicing factor SYF1; Involved in pre-mRNA splicing and cell cycle progression.
   
 0.999
CEF1
Pre-mRNA-splicing factor CEF1; Involved in pre-mRNA splicing and cell cycle control.
   
 0.997
PRP46
Pre-mRNA-splicing factor PRP46; Involved in pre-mRNA splicing and required for cell cycle progression at G2/M.
   
 0.996
KLLA0_D03883g
KLLA0D03883p.
   
 0.995
CWC2
Pre-mRNA-splicing factor CWC2; Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex. May provide the link between the 'nineteen complex' NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled active spliceosomes. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic [...]
    
 0.995
Your Current Organism:
Kluyveromyces lactis
NCBI taxonomy Id: 284590
Other names: K. lactis NRRL Y-1140, Kluyveromyces lactis NRRL Y-1140
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