node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABL64317.1 | ABL65158.1 | Cpha266_0250 | Cpha266_1118 | KEGG: cte:CT0173 phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: amino acid-binding ACT domain protein; Haloacid dehalogenase domain protein hydrolase; Haloacid dehalogenase domain protein hydrolase, type 3. | TIGRFAM: putative L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase, class I and II; KEGG: cch:Cag_1011 L-threonine-O-3-phosphate decarboxylase. | 0.529 |
ABL64317.1 | guaA | Cpha266_0250 | Cpha266_0300 | KEGG: cte:CT0173 phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: amino acid-binding ACT domain protein; Haloacid dehalogenase domain protein hydrolase; Haloacid dehalogenase domain protein hydrolase, type 3. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.552 |
ABL64317.1 | hisA | Cpha266_0250 | Cpha266_0492 | KEGG: cte:CT0173 phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: amino acid-binding ACT domain protein; Haloacid dehalogenase domain protein hydrolase; Haloacid dehalogenase domain protein hydrolase, type 3. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: plt:Plut_1690 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis. | 0.726 |
ABL64317.1 | hisB | Cpha266_0250 | Cpha266_0929 | KEGG: cte:CT0173 phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: amino acid-binding ACT domain protein; Haloacid dehalogenase domain protein hydrolase; Haloacid dehalogenase domain protein hydrolase, type 3. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: cch:Cag_1533 imidazoleglycerol-phosphate dehydratase. | 0.782 |
ABL64317.1 | hisC | Cpha266_0250 | Cpha266_1412 | KEGG: cte:CT0173 phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: amino acid-binding ACT domain protein; Haloacid dehalogenase domain protein hydrolase; Haloacid dehalogenase domain protein hydrolase, type 3. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; KEGG: cte:CT1256 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.529 |
ABL64317.1 | hisD | Cpha266_0250 | Cpha266_0801 | KEGG: cte:CT0173 phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: amino acid-binding ACT domain protein; Haloacid dehalogenase domain protein hydrolase; Haloacid dehalogenase domain protein hydrolase, type 3. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.730 |
ABL64317.1 | hisF | Cpha266_0250 | Cpha266_1907 | KEGG: cte:CT0173 phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: amino acid-binding ACT domain protein; Haloacid dehalogenase domain protein hydrolase; Haloacid dehalogenase domain protein hydrolase, type 3. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.805 |
ABL64317.1 | hisG | Cpha266_0250 | Cpha266_2357 | KEGG: cte:CT0173 phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: amino acid-binding ACT domain protein; Haloacid dehalogenase domain protein hydrolase; Haloacid dehalogenase domain protein hydrolase, type 3. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.493 |
ABL64317.1 | hisH | Cpha266_0250 | Cpha266_0491 | KEGG: cte:CT0173 phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: amino acid-binding ACT domain protein; Haloacid dehalogenase domain protein hydrolase; Haloacid dehalogenase domain protein hydrolase, type 3. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.721 |
ABL64317.1 | hisI | Cpha266_0250 | Cpha266_0479 | KEGG: cte:CT0173 phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: amino acid-binding ACT domain protein; Haloacid dehalogenase domain protein hydrolase; Haloacid dehalogenase domain protein hydrolase, type 3. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.782 |
ABL65158.1 | ABL64317.1 | Cpha266_1118 | Cpha266_0250 | TIGRFAM: putative L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase, class I and II; KEGG: cch:Cag_1011 L-threonine-O-3-phosphate decarboxylase. | KEGG: cte:CT0173 phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: amino acid-binding ACT domain protein; Haloacid dehalogenase domain protein hydrolase; Haloacid dehalogenase domain protein hydrolase, type 3. | 0.529 |
ABL65158.1 | hisA | Cpha266_1118 | Cpha266_0492 | TIGRFAM: putative L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase, class I and II; KEGG: cch:Cag_1011 L-threonine-O-3-phosphate decarboxylase. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: plt:Plut_1690 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis. | 0.773 |
ABL65158.1 | hisB | Cpha266_1118 | Cpha266_0929 | TIGRFAM: putative L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase, class I and II; KEGG: cch:Cag_1011 L-threonine-O-3-phosphate decarboxylase. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: cch:Cag_1533 imidazoleglycerol-phosphate dehydratase. | 0.895 |
ABL65158.1 | hisD | Cpha266_1118 | Cpha266_0801 | TIGRFAM: putative L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase, class I and II; KEGG: cch:Cag_1011 L-threonine-O-3-phosphate decarboxylase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.815 |
ABL65158.1 | hisF | Cpha266_1118 | Cpha266_1907 | TIGRFAM: putative L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase, class I and II; KEGG: cch:Cag_1011 L-threonine-O-3-phosphate decarboxylase. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.804 |
ABL65158.1 | hisG | Cpha266_1118 | Cpha266_2357 | TIGRFAM: putative L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase, class I and II; KEGG: cch:Cag_1011 L-threonine-O-3-phosphate decarboxylase. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.777 |
ABL65158.1 | hisH | Cpha266_1118 | Cpha266_0491 | TIGRFAM: putative L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase, class I and II; KEGG: cch:Cag_1011 L-threonine-O-3-phosphate decarboxylase. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.841 |
ABL65158.1 | hisI | Cpha266_1118 | Cpha266_0479 | TIGRFAM: putative L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase, class I and II; KEGG: cch:Cag_1011 L-threonine-O-3-phosphate decarboxylase. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.811 |
guaA | ABL64317.1 | Cpha266_0300 | Cpha266_0250 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | KEGG: cte:CT0173 phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: amino acid-binding ACT domain protein; Haloacid dehalogenase domain protein hydrolase; Haloacid dehalogenase domain protein hydrolase, type 3. | 0.552 |
guaA | hisA | Cpha266_0300 | Cpha266_0492 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: plt:Plut_1690 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis. | 0.750 |