STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dnaKChaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (640 aa)    
Predicted Functional Partners:
dnaJ
Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
 0.997
htpG
Heat shock protein Hsp90; Molecular chaperone. Has ATPase activity.
   
 0.954
grpE
GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
 
 0.933
groL
Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
 
 0.875
ABL66350.1
PFAM: nitrogen-fixing NifU domain protein; BFD domain protein [2Fe-2S]-binding domain protein; KEGG: plt:Plut_0236 IscU protein.
 
 
 0.846
ABL64393.1
PFAM: UvrB/UvrC protein; AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: cte:CT0191 ATP-dependent Clp protease, ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family.
  
 
 0.795
ABL66437.1
PFAM: AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase; KEGG: plt:Plut_0161 ATPase; Belongs to the ClpA/ClpB family.
  
 
 0.795
ABL66565.1
ATPase AAA-2 domain protein; PFAM: ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: cch:Cag_1973 ATPase.
  
 
 0.795
ABL65333.1
PFAM: helicase domain protein; SMART: DEAD-like helicases-like; KEGG: cya:CYA_0322 putative helicase.
  
 0.780
groS
Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.
 
 
 0.780
Your Current Organism:
Chlorobium phaeobacteroides DSM 266
NCBI taxonomy Id: 290317
Other names: C. phaeobacteroides DSM 266, Chlorobium phaeobacteroides DSMZ 266(T), Chlorobium phaeobacteroides str. DSM 266, Chlorobium phaeobacteroides strain DSM 266
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