STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sufSHypothetical protein; Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L- selenocysteine. Selenocysteine lyase activity is however unsure in vivo. (406 aa)    
Predicted Functional Partners:
sufE
Hypothetical protein; Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L- alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process; Belongs to the SufE family.
 
 0.996
CKO_01714
Hypothetical protein; COG: COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component.
 
 
 0.994
CKO_01715
Hypothetical protein; KEGG: noc:Noc_2489 1.8e-86 sufC; FeS assembly ATPase SufC K09013; COG: COG0396 ABC-type transport system involved in Fe-S cluster assembly, ATPase component.
 
  
 0.994
CKO_01716
Hypothetical protein; COG: COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component.
 
 
 0.994
CKO_00252
Hypothetical protein; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
  
 0.984
CKO_04175
Hypothetical protein; KEGG: cps:CPS_2211 2.2e-15 putative selenocysteine lyase K02426; COG: COG2166 SufE protein probably involved in Fe-S center assembly.
 
 0.935
CKO_02184
Hypothetical protein; KEGG: ecc:c1025 6.6e-167 trxB; thioredoxin reductase K00384; COG: COG0492 Thioredoxin reductase.
 
 
 0.925
selD
Hypothetical protein; Synthesizes selenophosphate from selenide and ATP.
   
 0.917
CKO_03055
Hypothetical protein; KEGG: eco:b3939 2.8e-198 metB, met-1, met1; cystathionine gamma-synthase K01739; COG: COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases; Psort location: Cytoplasmic, score:9.97.
     
 0.900
CKO_01717
Hypothetical protein; COG: COG0316 Uncharacterized conserved protein; Belongs to the HesB/IscA family.
 
 
 0.853
Your Current Organism:
Citrobacter koseri
NCBI taxonomy Id: 290338
Other names: C. koseri ATCC BAA-895, Citrobacter (diversus) koseri ATCC BAA-895, Citrobacter koseri ATCC BAA-895, Citrobacter koseri str. ATCC BAA-895, Citrobacter koseri strain ATCC BAA-895
Server load: medium (52%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.