node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CKO_04884 | bioB | CKO_04884 | CKO_02353 | Hypothetical protein; KEGG: eca:ECA2053 6.6e-167 gabT, goaG; 4-aminobutyrate aminotransferase K00823:K07250; COG: COG0160 4-aminobutyrate aminotransferase and related aminotransferases; Psort location: Cytoplasmic, score:8.96; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Hypothetical protein; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.874 |
CKO_04884 | bioD | CKO_04884 | CKO_01592 | Hypothetical protein; KEGG: eca:ECA2053 6.6e-167 gabT, goaG; 4-aminobutyrate aminotransferase K00823:K07250; COG: COG0160 4-aminobutyrate aminotransferase and related aminotransferases; Psort location: Cytoplasmic, score:8.96; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Hypothetical protein; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family. | 0.855 |
CKO_04884 | bioD-2 | CKO_04884 | CKO_02350 | Hypothetical protein; KEGG: eca:ECA2053 6.6e-167 gabT, goaG; 4-aminobutyrate aminotransferase K00823:K07250; COG: COG0160 4-aminobutyrate aminotransferase and related aminotransferases; Psort location: Cytoplasmic, score:8.96; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Hypothetical protein; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family. | 0.855 |
CKO_04884 | bioF | CKO_04884 | CKO_02352 | Hypothetical protein; KEGG: eca:ECA2053 6.6e-167 gabT, goaG; 4-aminobutyrate aminotransferase K00823:K07250; COG: COG0160 4-aminobutyrate aminotransferase and related aminotransferases; Psort location: Cytoplasmic, score:8.96; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Hypothetical protein; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.649 |
CKO_04884 | birA | CKO_04884 | CKO_03018 | Hypothetical protein; KEGG: eca:ECA2053 6.6e-167 gabT, goaG; 4-aminobutyrate aminotransferase K00823:K07250; COG: COG0160 4-aminobutyrate aminotransferase and related aminotransferases; Psort location: Cytoplasmic, score:8.96; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Hypothetical protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.471 |
CKO_04884 | kbl | CKO_04884 | CKO_05077 | Hypothetical protein; KEGG: eca:ECA2053 6.6e-167 gabT, goaG; 4-aminobutyrate aminotransferase K00823:K07250; COG: COG0160 4-aminobutyrate aminotransferase and related aminotransferases; Psort location: Cytoplasmic, score:8.96; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Hypothetical protein; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.649 |
CKO_05002 | bioB | CKO_05002 | CKO_02353 | Hypothetical protein; KEGG: stm:STM3644 0. bisC; biotin sulfoxide reductase K08351; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: Periplasmic, score:9.44; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | Hypothetical protein; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.900 |
CKO_05002 | birA | CKO_05002 | CKO_03018 | Hypothetical protein; KEGG: stm:STM3644 0. bisC; biotin sulfoxide reductase K08351; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: Periplasmic, score:9.44; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | Hypothetical protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.900 |
bioA | bioB | CKO_02354 | CKO_02353 | Hypothetical protein; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | Hypothetical protein; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.992 |
bioA | bioC | CKO_02354 | CKO_02351 | Hypothetical protein; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | Hypothetical protein; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. | 0.866 |
bioA | bioD | CKO_02354 | CKO_01592 | Hypothetical protein; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | Hypothetical protein; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family. | 0.994 |
bioA | bioD-2 | CKO_02354 | CKO_02350 | Hypothetical protein; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | Hypothetical protein; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family. | 0.999 |
bioA | bioF | CKO_02354 | CKO_02352 | Hypothetical protein; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | Hypothetical protein; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.995 |
bioA | birA | CKO_02354 | CKO_03018 | Hypothetical protein; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | Hypothetical protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.471 |
bioA | kbl | CKO_02354 | CKO_05077 | Hypothetical protein; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | Hypothetical protein; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.710 |
bioB | CKO_04884 | CKO_02353 | CKO_04884 | Hypothetical protein; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Hypothetical protein; KEGG: eca:ECA2053 6.6e-167 gabT, goaG; 4-aminobutyrate aminotransferase K00823:K07250; COG: COG0160 4-aminobutyrate aminotransferase and related aminotransferases; Psort location: Cytoplasmic, score:8.96; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.874 |
bioB | CKO_05002 | CKO_02353 | CKO_05002 | Hypothetical protein; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Hypothetical protein; KEGG: stm:STM3644 0. bisC; biotin sulfoxide reductase K08351; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: Periplasmic, score:9.44; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | 0.900 |
bioB | bioA | CKO_02353 | CKO_02354 | Hypothetical protein; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Hypothetical protein; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | 0.992 |
bioB | bioC | CKO_02353 | CKO_02351 | Hypothetical protein; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Hypothetical protein; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. | 0.982 |
bioB | bioD | CKO_02353 | CKO_01592 | Hypothetical protein; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Hypothetical protein; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family. | 0.995 |