node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AAur_1607 | hisA | AAur_1607 | AAur_1608 | Hypothetical protein; Identified by Glimmer2; putative. | Bifunctional HisA/TrpF protein; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR01919. | 0.629 |
AAur_1607 | hisB | AAur_1607 | AAur_1605 | Hypothetical protein; Identified by Glimmer2; putative. | Imidazoleglycerol-phosphate dehydratase (IGPD); Identified by match to protein family HMM PF00475. | 0.786 |
AAur_1607 | hisC | AAur_1607 | AAur_1604 | Hypothetical protein; Identified by Glimmer2; putative. | Histidinol-phosphate aminotransferase; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.634 |
AAur_1607 | hisH | AAur_1607 | AAur_1606 | Hypothetical protein; Identified by Glimmer2; putative. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.786 |
hisA | AAur_1607 | AAur_1608 | AAur_1607 | Bifunctional HisA/TrpF protein; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR01919. | Hypothetical protein; Identified by Glimmer2; putative. | 0.629 |
hisA | hisB | AAur_1608 | AAur_1605 | Bifunctional HisA/TrpF protein; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR01919. | Imidazoleglycerol-phosphate dehydratase (IGPD); Identified by match to protein family HMM PF00475. | 0.998 |
hisA | hisC | AAur_1608 | AAur_1604 | Bifunctional HisA/TrpF protein; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR01919. | Histidinol-phosphate aminotransferase; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.980 |
hisA | hisD | AAur_1608 | AAur_1724 | Bifunctional HisA/TrpF protein; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR01919. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.984 |
hisA | hisE | AAur_1608 | AAur_1830 | Bifunctional HisA/TrpF protein; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR01919. | Phosphoribosyl-ATP pyrophosphatase (PRA-PH); Identified by match to protein family HMM PF01503. | 0.953 |
hisA | hisF | AAur_1608 | AAur_1832 | Bifunctional HisA/TrpF protein; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR01919. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | AAur_1608 | AAur_1831 | Bifunctional HisA/TrpF protein; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR01919. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.979 |
hisA | hisH | AAur_1608 | AAur_1606 | Bifunctional HisA/TrpF protein; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR01919. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | AAur_1608 | AAur_1834 | Bifunctional HisA/TrpF protein; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR01919. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisA | pat | AAur_1608 | AAur_3894 | Bifunctional HisA/TrpF protein; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR01919. | Putative histidinol-phosphate aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | 0.798 |
hisB | AAur_1607 | AAur_1605 | AAur_1607 | Imidazoleglycerol-phosphate dehydratase (IGPD); Identified by match to protein family HMM PF00475. | Hypothetical protein; Identified by Glimmer2; putative. | 0.786 |
hisB | hisA | AAur_1605 | AAur_1608 | Imidazoleglycerol-phosphate dehydratase (IGPD); Identified by match to protein family HMM PF00475. | Bifunctional HisA/TrpF protein; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR01919. | 0.998 |
hisB | hisC | AAur_1605 | AAur_1604 | Imidazoleglycerol-phosphate dehydratase (IGPD); Identified by match to protein family HMM PF00475. | Histidinol-phosphate aminotransferase; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.999 |
hisB | hisD | AAur_1605 | AAur_1724 | Imidazoleglycerol-phosphate dehydratase (IGPD); Identified by match to protein family HMM PF00475. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.996 |
hisB | hisE | AAur_1605 | AAur_1830 | Imidazoleglycerol-phosphate dehydratase (IGPD); Identified by match to protein family HMM PF00475. | Phosphoribosyl-ATP pyrophosphatase (PRA-PH); Identified by match to protein family HMM PF01503. | 0.959 |
hisB | hisF | AAur_1605 | AAur_1832 | Imidazoleglycerol-phosphate dehydratase (IGPD); Identified by match to protein family HMM PF00475. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.998 |