STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
prcAPutative 20S proteasome alpha-subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. (247 aa)    
Predicted Functional Partners:
arc
Putative ATPase, AAA family domain protein; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.
 
 0.999
prcB
Putative 20S proteasome beta-subunit precursor; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family.
 
 0.999
pafA
Putative proteasome component; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine.
  
 0.991
AAur_0850
Conserved hypothetical protein.
  
 
 
 0.989
AAur_2175
Putative proteasome component; Identified by match to protein family HMM PF03136; match to protein family HMM PF03316.
  
 0.950
glpK
Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.
   
 0.840
AAur_2176
Conserved hypothetical protein.
       0.773
AAur_2182
Hypothetical protein; Identified by Glimmer2; putative.
 
   
 0.763
AAur_2180
Peptidyl-prolyl cis-trans isomerase, FKBP-type; Identified by match to protein family HMM PF00254.
   
 
 0.752
AAur_3806
Putative ATPase domain, AAA family protein; Identified by match to protein family HMM PF00004; match to protein family HMM PF00583; Belongs to the AAA ATPase family.
   
 0.740
Your Current Organism:
Paenarthrobacter aurescens
NCBI taxonomy Id: 290340
Other names: Arthrobacter aurescens TC1, P. aurescens TC1, Paenarthrobacter aurescens TC1
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.