STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AAur_4042Putative 3-carboxy-cis,cis-muconate cycloisomerase (pcaB); Identified by match to protein family HMM PF00206. (473 aa)    
Predicted Functional Partners:
pcaG
Protocatechuate 3,4-dioxygenase, alpha subunit; Identified by match to protein family HMM PF00775; match to protein family HMM TIGR02423.
 
 
 0.998
pcaH
Protocatechuate 3,4-dioxygenase, beta subunit; Identified by match to protein family HMM PF00775; match to protein family HMM TIGR02422.
 
 
 0.997
pcaC
4-carboxymuconolactone decarboxylase; Identified by match to protein family HMM PF02627; match to protein family HMM TIGR02425.
 
 
 0.989
purF
Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
 
 
 0.819
pobA
4-hydroxybenzoate hydroxylase; Identified by similarity to SP:P20586; match to protein family HMM PF01494.
 
  
 0.813
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
 
 
 0.804
guaA
GMP synthase (Glutamine amidotransferase); Catalyzes the synthesis of GMP from XMP.
 
  
 0.796
purC
Phosphoribosylaminoimidazole-succinocarboxamide synthase; Identified by match to protein family HMM PF01259; match to protein family HMM TIGR00081; Belongs to the SAICAR synthetase family.
  
 
 0.792
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
  
 0.785
purH
Bifunctional purine biosynthesis protein PurH; Identified by match to protein family HMM PF01808; match to protein family HMM PF02142; match to protein family HMM TIGR00355.
  
 
 0.782
Your Current Organism:
Paenarthrobacter aurescens
NCBI taxonomy Id: 290340
Other names: Arthrobacter aurescens TC1, P. aurescens TC1, Paenarthrobacter aurescens TC1
Server load: high (82%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.