STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lexASOS-response transcriptional repressor, LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (288 aa)    
Predicted Functional Partners:
recA
recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 0.922
dinB
DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
 
 
 0.795
Arth_3841
DNA-directed DNA polymerase; PFAM: UMUC domain protein DNA-repair protein; KEGG: rfr:Rfer_4341 DNA-directed DNA polymerase.
 
 
 0.775
Arth_2021
DNA-directed DNA polymerase; PFAM: UMUC domain protein DNA-repair protein; KEGG: nfa:nfa56150 putative DNA polymerase IV family protein.
 
 
 0.760
Arth_1518
DNA replication and repair protein RecN; May be involved in recombinational repair of damaged DNA.
  
  
 0.671
Arth_1469
PFAM: Peptidoglycan-binding LysM; KEGG: lxx:Lxx15870 conserved ypothetical protein.
  
  
 0.617
argR
Transcriptional regulator, ArgR family; Regulates arginine biosynthesis genes.
  
   
 0.552
Arth_1454
PFAM: cell divisionFtsK/SpoIIIE; SMART: AAA ATPase; KEGG: sma:SAV2510 putative FtsK; Belongs to the FtsK/SpoIIIE/SftA family.
 
   
 0.530
Arth_1569
Cell division-specific peptidoglycan biosynthesis regulator FtsW; TIGRFAM: cell division protein FtsW; PFAM: cell cycle protein; KEGG: lxx:Lxx15270 cell division protein; Belongs to the SEDS family.
  
   
 0.528
recF
DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.
  
  
 0.526
Your Current Organism:
Arthrobacter sp. FB24
NCBI taxonomy Id: 290399
Other names: A. sp. FB24
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