STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hisGAtp phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (286 aa)    
Predicted Functional Partners:
hisE
PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: tfu:Tfu_0175 phosphoribosyl-ATP pyrophosphatase
 
 
 0.996
hisF
Imidazole glycerol-phosphate synthase subunit hisf; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
 
 
 0.991
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
 
 
 0.989
hisI
Phosphoribosyl-amp cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
 
  
 0.976
hisB
PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: blo:BL1297 imidazoleglycerol-phosphate dehydratase
 
  
 0.967
hisH
Imidazole glycerol-phosphate synthase subunit hish; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF
 
  
 0.961
hisC
Histidinol phosphate aminotransferase apoenzyme; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
 
  
 0.933
hisA
KEGG: lxx:Lxx15830 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; TIGRFAM: bifunctional HisA/TrpF protein; PFAM: histidine biosynthesis
 
  
 0.926
prs
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P)
  
 
 0.844
Arth_2012
Acyl-coa carboxylase subunit beta; PFAM: carboxyl transferase; KEGG: mpa:MAP0839c acetyl-CoA carboxylase carboxyl transferase
     
 0.759
Your Current Organism:
Arthrobacter sp. FB24
NCBI taxonomy Id: 290399
Other names: A. sp. FB24
Server load: low (14%) [HD]