node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arth_0225 | arc | Arth_0225 | Arth_2173 | PDZ/DHR/GLGF domain protein; PFAM: peptidase S1 and S6, chymotrypsin/Hap; PDZ/DHR/GLGF domain protein; KEGG: fra:Francci3_1988 peptidase S1 and S6, chymotrypsin/Hap. | Vesicle-fusing ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.780 |
Arth_0225 | glpK | Arth_0225 | Arth_1803 | PDZ/DHR/GLGF domain protein; PFAM: peptidase S1 and S6, chymotrypsin/Hap; PDZ/DHR/GLGF domain protein; KEGG: fra:Francci3_1988 peptidase S1 and S6, chymotrypsin/Hap. | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. | 0.563 |
Arth_0225 | glpK-2 | Arth_0225 | Arth_2248 | PDZ/DHR/GLGF domain protein; PFAM: peptidase S1 and S6, chymotrypsin/Hap; PDZ/DHR/GLGF domain protein; KEGG: fra:Francci3_1988 peptidase S1 and S6, chymotrypsin/Hap. | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. | 0.563 |
Arth_0225 | prcA | Arth_0225 | Arth_2177 | PDZ/DHR/GLGF domain protein; PFAM: peptidase S1 and S6, chymotrypsin/Hap; PDZ/DHR/GLGF domain protein; KEGG: fra:Francci3_1988 peptidase S1 and S6, chymotrypsin/Hap. | 20S proteasome, A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.416 |
Arth_0225 | prcB | Arth_0225 | Arth_2176 | PDZ/DHR/GLGF domain protein; PFAM: peptidase S1 and S6, chymotrypsin/Hap; PDZ/DHR/GLGF domain protein; KEGG: fra:Francci3_1988 peptidase S1 and S6, chymotrypsin/Hap. | Proteasome endopeptidase complex, beta component, Threonine peptidase, MEROPS family T01B; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.416 |
Arth_2172 | Arth_2174 | Arth_2172 | Arth_2174 | tRNA (adenine-58-N(1)-) methyltransferase; Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA. | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: tfu:Tfu_1796 putative proteasome component. | 0.724 |
Arth_2172 | arc | Arth_2172 | Arth_2173 | tRNA (adenine-58-N(1)-) methyltransferase; Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA. | Vesicle-fusing ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.800 |
Arth_2172 | pafA | Arth_2172 | Arth_2178 | tRNA (adenine-58-N(1)-) methyltransferase; Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA. | Protein of unknown function DUF245 domain protein; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.620 |
Arth_2172 | prcA | Arth_2172 | Arth_2177 | tRNA (adenine-58-N(1)-) methyltransferase; Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA. | 20S proteasome, A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.463 |
Arth_2172 | prcB | Arth_2172 | Arth_2176 | tRNA (adenine-58-N(1)-) methyltransferase; Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA. | Proteasome endopeptidase complex, beta component, Threonine peptidase, MEROPS family T01B; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.541 |
Arth_2172 | pup | Arth_2172 | Arth_2175 | tRNA (adenine-58-N(1)-) methyltransferase; Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA. | Protein of unknown function DUF797; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. | 0.597 |
Arth_2174 | Arth_2172 | Arth_2174 | Arth_2172 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: tfu:Tfu_1796 putative proteasome component. | tRNA (adenine-58-N(1)-) methyltransferase; Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA. | 0.724 |
Arth_2174 | arc | Arth_2174 | Arth_2173 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: tfu:Tfu_1796 putative proteasome component. | Vesicle-fusing ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.958 |
Arth_2174 | pafA | Arth_2174 | Arth_2178 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: tfu:Tfu_1796 putative proteasome component. | Protein of unknown function DUF245 domain protein; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.662 |
Arth_2174 | prcA | Arth_2174 | Arth_2177 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: tfu:Tfu_1796 putative proteasome component. | 20S proteasome, A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.926 |
Arth_2174 | prcB | Arth_2174 | Arth_2176 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: tfu:Tfu_1796 putative proteasome component. | Proteasome endopeptidase complex, beta component, Threonine peptidase, MEROPS family T01B; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.920 |
Arth_2174 | pup | Arth_2174 | Arth_2175 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: tfu:Tfu_1796 putative proteasome component. | Protein of unknown function DUF797; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. | 0.949 |
Arth_3981 | arc | Arth_3981 | Arth_2173 | PFAM: GCN5-related N-acetyltransferase; AAA ATPase, central domain protein; SMART: AAA ATPase; KEGG: fra:Francci3_3406 AAA ATPase, central region; Belongs to the AAA ATPase family. | Vesicle-fusing ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.923 |
arc | Arth_0225 | Arth_2173 | Arth_0225 | Vesicle-fusing ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | PDZ/DHR/GLGF domain protein; PFAM: peptidase S1 and S6, chymotrypsin/Hap; PDZ/DHR/GLGF domain protein; KEGG: fra:Francci3_1988 peptidase S1 and S6, chymotrypsin/Hap. | 0.780 |
arc | Arth_2172 | Arth_2173 | Arth_2172 | Vesicle-fusing ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | tRNA (adenine-58-N(1)-) methyltransferase; Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA. | 0.800 |