node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arth_0683 | Arth_2174 | Arth_0683 | Arth_2174 | KEGG: nfa:nfa2200 hypothetical protein. | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: tfu:Tfu_1796 putative proteasome component. | 0.667 |
Arth_0683 | arc | Arth_0683 | Arth_2173 | KEGG: nfa:nfa2200 hypothetical protein. | Vesicle-fusing ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.780 |
Arth_0683 | pafA | Arth_0683 | Arth_2178 | KEGG: nfa:nfa2200 hypothetical protein. | Protein of unknown function DUF245 domain protein; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.715 |
Arth_0683 | prcA | Arth_0683 | Arth_2177 | KEGG: nfa:nfa2200 hypothetical protein. | 20S proteasome, A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.988 |
Arth_0683 | prcB | Arth_0683 | Arth_2176 | KEGG: nfa:nfa2200 hypothetical protein. | Proteasome endopeptidase complex, beta component, Threonine peptidase, MEROPS family T01B; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.930 |
Arth_0683 | pup | Arth_0683 | Arth_2175 | KEGG: nfa:nfa2200 hypothetical protein. | Protein of unknown function DUF797; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. | 0.420 |
Arth_2174 | Arth_0683 | Arth_2174 | Arth_0683 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: tfu:Tfu_1796 putative proteasome component. | KEGG: nfa:nfa2200 hypothetical protein. | 0.667 |
Arth_2174 | Arth_2179 | Arth_2174 | Arth_2179 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: tfu:Tfu_1796 putative proteasome component. | PFAM: peptidylprolyl isomerase, FKBP-type; KEGG: blo:BL0354 possible secreted peptidyl-prolyl cis-trans isomerase protein. | 0.527 |
Arth_2174 | Arth_2181 | Arth_2174 | Arth_2181 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: tfu:Tfu_1796 putative proteasome component. | KEGG: tfu:Tfu_1771 similar to transcriptional regulator. | 0.459 |
Arth_2174 | arc | Arth_2174 | Arth_2173 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: tfu:Tfu_1796 putative proteasome component. | Vesicle-fusing ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.958 |
Arth_2174 | pafA | Arth_2174 | Arth_2178 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: tfu:Tfu_1796 putative proteasome component. | Protein of unknown function DUF245 domain protein; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.662 |
Arth_2174 | prcA | Arth_2174 | Arth_2177 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: tfu:Tfu_1796 putative proteasome component. | 20S proteasome, A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.926 |
Arth_2174 | prcB | Arth_2174 | Arth_2176 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: tfu:Tfu_1796 putative proteasome component. | Proteasome endopeptidase complex, beta component, Threonine peptidase, MEROPS family T01B; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.920 |
Arth_2174 | pup | Arth_2174 | Arth_2175 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: tfu:Tfu_1796 putative proteasome component. | Protein of unknown function DUF797; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. | 0.949 |
Arth_2179 | Arth_2174 | Arth_2179 | Arth_2174 | PFAM: peptidylprolyl isomerase, FKBP-type; KEGG: blo:BL0354 possible secreted peptidyl-prolyl cis-trans isomerase protein. | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: tfu:Tfu_1796 putative proteasome component. | 0.527 |
Arth_2179 | Arth_2180 | Arth_2179 | Arth_2180 | PFAM: peptidylprolyl isomerase, FKBP-type; KEGG: blo:BL0354 possible secreted peptidyl-prolyl cis-trans isomerase protein. | PFAM: peptidylprolyl isomerase, FKBP-type; KEGG: sma:SAV6687 putative FK-506 binding protein, peptidyl-prolyl cis-trans isomerase. | 0.821 |
Arth_2179 | Arth_2181 | Arth_2179 | Arth_2181 | PFAM: peptidylprolyl isomerase, FKBP-type; KEGG: blo:BL0354 possible secreted peptidyl-prolyl cis-trans isomerase protein. | KEGG: tfu:Tfu_1771 similar to transcriptional regulator. | 0.597 |
Arth_2179 | arc | Arth_2179 | Arth_2173 | PFAM: peptidylprolyl isomerase, FKBP-type; KEGG: blo:BL0354 possible secreted peptidyl-prolyl cis-trans isomerase protein. | Vesicle-fusing ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.470 |
Arth_2179 | pafA | Arth_2179 | Arth_2178 | PFAM: peptidylprolyl isomerase, FKBP-type; KEGG: blo:BL0354 possible secreted peptidyl-prolyl cis-trans isomerase protein. | Protein of unknown function DUF245 domain protein; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.668 |
Arth_2179 | prcA | Arth_2179 | Arth_2177 | PFAM: peptidylprolyl isomerase, FKBP-type; KEGG: blo:BL0354 possible secreted peptidyl-prolyl cis-trans isomerase protein. | 20S proteasome, A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.687 |