node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arth_0590 | Arth_1691 | Arth_0590 | Arth_1691 | Pyruvate dehydrogenase (cytochrome); PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: pac:PPA1468 pyruvate dehydrogenase; Belongs to the TPP enzyme family. | PFAM: glutamine amidotransferase, class-II; glutamate synthase, alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: lxx:Lxx11320 glutamate synthase, alpha subunit. | 0.582 |
Arth_0590 | Arth_1693 | Arth_0590 | Arth_1693 | Pyruvate dehydrogenase (cytochrome); PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: pac:PPA1468 pyruvate dehydrogenase; Belongs to the TPP enzyme family. | PFAM: pyruvate kinase; KEGG: lxx:Lxx11340 pyruvate kinase II; Belongs to the pyruvate kinase family. | 0.922 |
Arth_0590 | Arth_2538 | Arth_0590 | Arth_2538 | Pyruvate dehydrogenase (cytochrome); PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: pac:PPA1468 pyruvate dehydrogenase; Belongs to the TPP enzyme family. | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: tfu:Tfu_0612 acetolactate synthase, small subunit. | 0.970 |
Arth_0590 | ilvC | Arth_0590 | Arth_2537 | Pyruvate dehydrogenase (cytochrome); PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: pac:PPA1468 pyruvate dehydrogenase; Belongs to the TPP enzyme family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.650 |
Arth_0590 | ilvD | Arth_0590 | Arth_2540 | Pyruvate dehydrogenase (cytochrome); PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: pac:PPA1468 pyruvate dehydrogenase; Belongs to the TPP enzyme family. | KEGG: lxx:Lxx13210 dihydroxy-acid dehydratase protein; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.649 |
Arth_0590 | ldh | Arth_0590 | Arth_3978 | Pyruvate dehydrogenase (cytochrome); PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: pac:PPA1468 pyruvate dehydrogenase; Belongs to the TPP enzyme family. | Malate dehydrogenase (NAD); Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. | 0.926 |
Arth_0590 | leuA | Arth_0590 | Arth_2226 | Pyruvate dehydrogenase (cytochrome); PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: pac:PPA1468 pyruvate dehydrogenase; Belongs to the TPP enzyme family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.879 |
Arth_0590 | leuB | Arth_0590 | Arth_2530 | Pyruvate dehydrogenase (cytochrome); PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: pac:PPA1468 pyruvate dehydrogenase; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. | 0.530 |
Arth_0590 | leuC | Arth_0590 | Arth_2519 | Pyruvate dehydrogenase (cytochrome); PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: pac:PPA1468 pyruvate dehydrogenase; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.885 |
Arth_0590 | leuD | Arth_0590 | Arth_2518 | Pyruvate dehydrogenase (cytochrome); PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: pac:PPA1468 pyruvate dehydrogenase; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.913 |
Arth_1691 | Arth_0590 | Arth_1691 | Arth_0590 | PFAM: glutamine amidotransferase, class-II; glutamate synthase, alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: lxx:Lxx11320 glutamate synthase, alpha subunit. | Pyruvate dehydrogenase (cytochrome); PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: pac:PPA1468 pyruvate dehydrogenase; Belongs to the TPP enzyme family. | 0.582 |
Arth_1691 | Arth_1693 | Arth_1691 | Arth_1693 | PFAM: glutamine amidotransferase, class-II; glutamate synthase, alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: lxx:Lxx11320 glutamate synthase, alpha subunit. | PFAM: pyruvate kinase; KEGG: lxx:Lxx11340 pyruvate kinase II; Belongs to the pyruvate kinase family. | 0.922 |
Arth_1691 | Arth_2538 | Arth_1691 | Arth_2538 | PFAM: glutamine amidotransferase, class-II; glutamate synthase, alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: lxx:Lxx11320 glutamate synthase, alpha subunit. | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: tfu:Tfu_0612 acetolactate synthase, small subunit. | 0.842 |
Arth_1691 | ilvC | Arth_1691 | Arth_2537 | PFAM: glutamine amidotransferase, class-II; glutamate synthase, alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: lxx:Lxx11320 glutamate synthase, alpha subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.905 |
Arth_1691 | ilvD | Arth_1691 | Arth_2540 | PFAM: glutamine amidotransferase, class-II; glutamate synthase, alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: lxx:Lxx11320 glutamate synthase, alpha subunit. | KEGG: lxx:Lxx13210 dihydroxy-acid dehydratase protein; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.918 |
Arth_1691 | ldh | Arth_1691 | Arth_3978 | PFAM: glutamine amidotransferase, class-II; glutamate synthase, alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: lxx:Lxx11320 glutamate synthase, alpha subunit. | Malate dehydrogenase (NAD); Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. | 0.750 |
Arth_1691 | leuA | Arth_1691 | Arth_2226 | PFAM: glutamine amidotransferase, class-II; glutamate synthase, alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: lxx:Lxx11320 glutamate synthase, alpha subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.651 |
Arth_1691 | leuB | Arth_1691 | Arth_2530 | PFAM: glutamine amidotransferase, class-II; glutamate synthase, alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: lxx:Lxx11320 glutamate synthase, alpha subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. | 0.782 |
Arth_1691 | leuC | Arth_1691 | Arth_2519 | PFAM: glutamine amidotransferase, class-II; glutamate synthase, alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: lxx:Lxx11320 glutamate synthase, alpha subunit. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.880 |
Arth_1691 | leuD | Arth_1691 | Arth_2518 | PFAM: glutamine amidotransferase, class-II; glutamate synthase, alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: lxx:Lxx11320 glutamate synthase, alpha subunit. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.825 |