node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arth_2529 | Arth_2538 | Arth_2529 | Arth_2538 | TIGRFAM: branched-chain amino acid aminotransferase; PFAM: aminotransferase, class IV; KEGG: xac:XAC0927 branched-chain amino acid aminotransferase. | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: tfu:Tfu_0612 acetolactate synthase, small subunit. | 0.697 |
Arth_2529 | Arth_2539 | Arth_2529 | Arth_2539 | TIGRFAM: branched-chain amino acid aminotransferase; PFAM: aminotransferase, class IV; KEGG: xac:XAC0927 branched-chain amino acid aminotransferase. | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: tfu:Tfu_0611 acetolactate synthase, large subunit, biosynthetic type. | 0.514 |
Arth_2529 | Arth_2838 | Arth_2529 | Arth_2838 | TIGRFAM: branched-chain amino acid aminotransferase; PFAM: aminotransferase, class IV; KEGG: xac:XAC0927 branched-chain amino acid aminotransferase. | PFAM: aminotransferase, class I and II; KEGG: psb:Psyr_3615 aminotransferase, class I and II. | 0.912 |
Arth_2529 | ilvC | Arth_2529 | Arth_2537 | TIGRFAM: branched-chain amino acid aminotransferase; PFAM: aminotransferase, class IV; KEGG: xac:XAC0927 branched-chain amino acid aminotransferase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.809 |
Arth_2529 | ilvD | Arth_2529 | Arth_2540 | TIGRFAM: branched-chain amino acid aminotransferase; PFAM: aminotransferase, class IV; KEGG: xac:XAC0927 branched-chain amino acid aminotransferase. | KEGG: lxx:Lxx13210 dihydroxy-acid dehydratase protein; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.989 |
Arth_2529 | leuA | Arth_2529 | Arth_2226 | TIGRFAM: branched-chain amino acid aminotransferase; PFAM: aminotransferase, class IV; KEGG: xac:XAC0927 branched-chain amino acid aminotransferase. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.986 |
Arth_2529 | leuB | Arth_2529 | Arth_2530 | TIGRFAM: branched-chain amino acid aminotransferase; PFAM: aminotransferase, class IV; KEGG: xac:XAC0927 branched-chain amino acid aminotransferase. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. | 0.853 |
Arth_2529 | leuC | Arth_2529 | Arth_2519 | TIGRFAM: branched-chain amino acid aminotransferase; PFAM: aminotransferase, class IV; KEGG: xac:XAC0927 branched-chain amino acid aminotransferase. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.775 |
Arth_2529 | leuD | Arth_2529 | Arth_2518 | TIGRFAM: branched-chain amino acid aminotransferase; PFAM: aminotransferase, class IV; KEGG: xac:XAC0927 branched-chain amino acid aminotransferase. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.506 |
Arth_2529 | panB | Arth_2529 | Arth_1591 | TIGRFAM: branched-chain amino acid aminotransferase; PFAM: aminotransferase, class IV; KEGG: xac:XAC0927 branched-chain amino acid aminotransferase. | Ketopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.916 |
Arth_2538 | Arth_2529 | Arth_2538 | Arth_2529 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: tfu:Tfu_0612 acetolactate synthase, small subunit. | TIGRFAM: branched-chain amino acid aminotransferase; PFAM: aminotransferase, class IV; KEGG: xac:XAC0927 branched-chain amino acid aminotransferase. | 0.697 |
Arth_2538 | Arth_2539 | Arth_2538 | Arth_2539 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: tfu:Tfu_0612 acetolactate synthase, small subunit. | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: tfu:Tfu_0611 acetolactate synthase, large subunit, biosynthetic type. | 0.999 |
Arth_2538 | ilvC | Arth_2538 | Arth_2537 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: tfu:Tfu_0612 acetolactate synthase, small subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.999 |
Arth_2538 | ilvD | Arth_2538 | Arth_2540 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: tfu:Tfu_0612 acetolactate synthase, small subunit. | KEGG: lxx:Lxx13210 dihydroxy-acid dehydratase protein; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.965 |
Arth_2538 | leuA | Arth_2538 | Arth_2226 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: tfu:Tfu_0612 acetolactate synthase, small subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.973 |
Arth_2538 | leuB | Arth_2538 | Arth_2530 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: tfu:Tfu_0612 acetolactate synthase, small subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. | 0.994 |
Arth_2538 | leuC | Arth_2538 | Arth_2519 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: tfu:Tfu_0612 acetolactate synthase, small subunit. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.846 |
Arth_2538 | leuD | Arth_2538 | Arth_2518 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: tfu:Tfu_0612 acetolactate synthase, small subunit. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.888 |
Arth_2539 | Arth_2529 | Arth_2539 | Arth_2529 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: tfu:Tfu_0611 acetolactate synthase, large subunit, biosynthetic type. | TIGRFAM: branched-chain amino acid aminotransferase; PFAM: aminotransferase, class IV; KEGG: xac:XAC0927 branched-chain amino acid aminotransferase. | 0.514 |
Arth_2539 | Arth_2538 | Arth_2539 | Arth_2538 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: tfu:Tfu_0611 acetolactate synthase, large subunit, biosynthetic type. | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: tfu:Tfu_0612 acetolactate synthase, small subunit. | 0.999 |