node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arth_2765 | Arth_2766 | Arth_2765 | Arth_2766 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: sco:SCO3311 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.977 |
Arth_2765 | Arth_2769 | Arth_2765 | Arth_2769 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: sco:SCO3311 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | PFAM: Chlorite dismutase; KEGG: sco:SCO6042 hypothetical protein. | 0.846 |
Arth_2765 | Arth_2771 | Arth_2765 | Arth_2771 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: sco:SCO3311 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | TIGRFAM: protoporphyrinogen oxidase; PFAM: FAD dependent oxidoreductase; KEGG: lxx:Lxx01060 protoporphyrinogen oxidase. | 0.810 |
Arth_2765 | Arth_3111 | Arth_2765 | Arth_3111 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: sco:SCO3311 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | TIGRFAM: uroporphyrin-III C-methyltransferase; siroheme synthase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: tfu:Tfu_2221 uroporphyrin-III C-methyltransferase, C-terminal:siroheme synthase, N-terminal. | 0.937 |
Arth_2765 | hemA | Arth_2765 | Arth_2773 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: sco:SCO3311 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.961 |
Arth_2765 | hemC | Arth_2765 | Arth_2767 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: sco:SCO3311 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.999 |
Arth_2765 | hemE | Arth_2765 | Arth_2772 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: sco:SCO3311 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.914 |
Arth_2765 | hemH | Arth_2765 | Arth_2768 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: sco:SCO3311 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.894 |
Arth_2765 | hemL | Arth_2765 | Arth_2763 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: sco:SCO3311 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase, class I and II; aminotransferase class-III; KEGG: lxx:Lxx01130 glutamate-1-semialdehyde 2,1-aminomutase. | 0.999 |
Arth_2766 | Arth_2765 | Arth_2766 | Arth_2765 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: sco:SCO3311 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.977 |
Arth_2766 | Arth_2769 | Arth_2766 | Arth_2769 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | PFAM: Chlorite dismutase; KEGG: sco:SCO6042 hypothetical protein. | 0.853 |
Arth_2766 | Arth_2771 | Arth_2766 | Arth_2771 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | TIGRFAM: protoporphyrinogen oxidase; PFAM: FAD dependent oxidoreductase; KEGG: lxx:Lxx01060 protoporphyrinogen oxidase. | 0.713 |
Arth_2766 | Arth_3111 | Arth_2766 | Arth_3111 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | TIGRFAM: uroporphyrin-III C-methyltransferase; siroheme synthase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: tfu:Tfu_2221 uroporphyrin-III C-methyltransferase, C-terminal:siroheme synthase, N-terminal. | 0.984 |
Arth_2766 | hemA | Arth_2766 | Arth_2773 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.868 |
Arth_2766 | hemC | Arth_2766 | Arth_2767 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.997 |
Arth_2766 | hemE | Arth_2766 | Arth_2772 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.962 |
Arth_2766 | hemH | Arth_2766 | Arth_2768 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.868 |
Arth_2766 | hemL | Arth_2766 | Arth_2763 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase, class I and II; aminotransferase class-III; KEGG: lxx:Lxx01130 glutamate-1-semialdehyde 2,1-aminomutase. | 0.950 |
Arth_2769 | Arth_2765 | Arth_2769 | Arth_2765 | PFAM: Chlorite dismutase; KEGG: sco:SCO6042 hypothetical protein. | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: sco:SCO3311 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.846 |
Arth_2769 | Arth_2766 | Arth_2769 | Arth_2766 | PFAM: Chlorite dismutase; KEGG: sco:SCO6042 hypothetical protein. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.853 |