STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thiEThiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (237 aa)    
Predicted Functional Partners:
Arth_2392
Phosphomethylpyrimidine kinase; KEGG: cef:CE1591 putative thiamin biosynthesis protein; TIGRFAM: phosphomethylpyrimidine kinase; PFAM: TENA/THI-4 domain protein; Phosphomethylpyrimidine kinase type-1.
 
 0.999
thiG
Thiazole-phosphate synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
  
 0.989
Arth_0593
PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: pac:PPA1712 putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase.
 
 0.970
thiL
Thiamine-phosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family.
    
 0.945
Arth_2780
TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: thiamineS protein; KEGG: sma:SAV6094 thiamine biosynthesis ThiS.
 
  
 0.936
rsgA
GTPase EngC; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
     
 0.909
rsgA-2
Ribosome small subunit-dependent GTPase A; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
     
 0.909
Arth_2781
TIGRFAM: glycine oxidase ThiO; PFAM: FAD dependent oxidoreductase; KEGG: pac:PPA0520 FAD dependent oxidoreductase.
 
  
 0.897
thiC
Hydroxymethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
 
  
 0.871
Arth_2774
PFAM: UBA/THIF-type NAD/FAD binding protein; Rhodanese domain protein; MoeZ/MoeB domain protein; KEGG: tfu:Tfu_0520 rhodanese-like protein.
 
  
 0.828
Your Current Organism:
Arthrobacter sp. FB24
NCBI taxonomy Id: 290399
Other names: A. sp. FB24
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