node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arth_1079 | Arth_3284 | Arth_1079 | Arth_3284 | PFAM: Enoyl-CoA hydratase/isomerase; KEGG: jan:Jann_3750 enoyl-CoA hydratase/isomerase; Belongs to the enoyl-CoA hydratase/isomerase family. | PFAM: AMP-dependent synthetase and ligase; KEGG: lxx:Lxx01450 O-succinylbenzoate-CoA ligase. | 0.591 |
Arth_1079 | menD | Arth_1079 | Arth_3138 | PFAM: Enoyl-CoA hydratase/isomerase; KEGG: jan:Jann_3750 enoyl-CoA hydratase/isomerase; Belongs to the enoyl-CoA hydratase/isomerase family. | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). | 0.432 |
Arth_3133 | Arth_3284 | Arth_3133 | Arth_3284 | TIGRFAM: isochorismate synthases; PFAM: Anthranilate synthase component I and chorismate binding protein; KEGG: lxx:Lxx01810 isochorismate mutase. | PFAM: AMP-dependent synthetase and ligase; KEGG: lxx:Lxx01450 O-succinylbenzoate-CoA ligase. | 0.581 |
Arth_3133 | menA | Arth_3133 | Arth_3285 | TIGRFAM: isochorismate synthases; PFAM: Anthranilate synthase component I and chorismate binding protein; KEGG: lxx:Lxx01810 isochorismate mutase. | 1,4-dihydroxy-2-naphtoate prenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. | 0.692 |
Arth_3133 | menB | Arth_3133 | Arth_3283 | TIGRFAM: isochorismate synthases; PFAM: Anthranilate synthase component I and chorismate binding protein; KEGG: lxx:Lxx01810 isochorismate mutase. | 1,4-Dihydroxy-2-naphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA); Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily. | 0.886 |
Arth_3133 | menC | Arth_3133 | Arth_3153 | TIGRFAM: isochorismate synthases; PFAM: Anthranilate synthase component I and chorismate binding protein; KEGG: lxx:Lxx01810 isochorismate mutase. | Mandelate racemase/muconate lactonizing enzyme, C-terminal domain protein; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). | 0.691 |
Arth_3133 | menD | Arth_3133 | Arth_3138 | TIGRFAM: isochorismate synthases; PFAM: Anthranilate synthase component I and chorismate binding protein; KEGG: lxx:Lxx01810 isochorismate mutase. | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). | 0.988 |
Arth_3133 | menG | Arth_3133 | Arth_3132 | TIGRFAM: isochorismate synthases; PFAM: Anthranilate synthase component I and chorismate binding protein; KEGG: lxx:Lxx01810 isochorismate mutase. | 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase / demethylmenaquinone methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). | 0.802 |
Arth_3137 | menD | Arth_3137 | Arth_3138 | KEGG: cef:CE2646 hypothetical protein. | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). | 0.471 |
Arth_3284 | Arth_1079 | Arth_3284 | Arth_1079 | PFAM: AMP-dependent synthetase and ligase; KEGG: lxx:Lxx01450 O-succinylbenzoate-CoA ligase. | PFAM: Enoyl-CoA hydratase/isomerase; KEGG: jan:Jann_3750 enoyl-CoA hydratase/isomerase; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.591 |
Arth_3284 | Arth_3133 | Arth_3284 | Arth_3133 | PFAM: AMP-dependent synthetase and ligase; KEGG: lxx:Lxx01450 O-succinylbenzoate-CoA ligase. | TIGRFAM: isochorismate synthases; PFAM: Anthranilate synthase component I and chorismate binding protein; KEGG: lxx:Lxx01810 isochorismate mutase. | 0.581 |
Arth_3284 | menA | Arth_3284 | Arth_3285 | PFAM: AMP-dependent synthetase and ligase; KEGG: lxx:Lxx01450 O-succinylbenzoate-CoA ligase. | 1,4-dihydroxy-2-naphtoate prenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. | 0.901 |
Arth_3284 | menB | Arth_3284 | Arth_3283 | PFAM: AMP-dependent synthetase and ligase; KEGG: lxx:Lxx01450 O-succinylbenzoate-CoA ligase. | 1,4-Dihydroxy-2-naphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA); Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily. | 0.994 |
Arth_3284 | menC | Arth_3284 | Arth_3153 | PFAM: AMP-dependent synthetase and ligase; KEGG: lxx:Lxx01450 O-succinylbenzoate-CoA ligase. | Mandelate racemase/muconate lactonizing enzyme, C-terminal domain protein; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). | 0.966 |
Arth_3284 | menD | Arth_3284 | Arth_3138 | PFAM: AMP-dependent synthetase and ligase; KEGG: lxx:Lxx01450 O-succinylbenzoate-CoA ligase. | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). | 0.787 |
dxs | ispE | Arth_1645 | Arth_1214 | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | 0.914 |
dxs | menD | Arth_1645 | Arth_3138 | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). | 0.420 |
dxs | menG | Arth_1645 | Arth_3132 | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase / demethylmenaquinone methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). | 0.508 |
ispE | dxs | Arth_1214 | Arth_1645 | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | 0.914 |
ispE | menD | Arth_1214 | Arth_3138 | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). | 0.450 |