node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Jann_1481 | Jann_1596 | Jann_1481 | Jann_1596 | FAD dependent oxidoreductase; Belongs to the GcvT family. | Dimethylglycine dehydrogenase; Belongs to the GcvT family. | 0.770 |
Jann_1481 | Jann_2079 | Jann_1481 | Jann_2079 | FAD dependent oxidoreductase; Belongs to the GcvT family. | Serine hydroxymethyltransferase. | 0.478 |
Jann_1481 | Jann_2186 | Jann_1481 | Jann_2186 | FAD dependent oxidoreductase; Belongs to the GcvT family. | Sarcosine oxidase alpha subunit family; Belongs to the GcvT family. | 0.930 |
Jann_1481 | Jann_2488 | Jann_1481 | Jann_2488 | FAD dependent oxidoreductase; Belongs to the GcvT family. | Dimethylglycine dehydrogenase; Belongs to the GcvT family. | 0.731 |
Jann_1481 | Jann_3447 | Jann_1481 | Jann_3447 | FAD dependent oxidoreductase; Belongs to the GcvT family. | Sarcosine oxidase alpha subunit family; Belongs to the GcvT family. | 0.823 |
Jann_1481 | gcvH | Jann_1481 | Jann_3621 | FAD dependent oxidoreductase; Belongs to the GcvT family. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.845 |
Jann_1481 | gcvP | Jann_1481 | Jann_3622 | FAD dependent oxidoreductase; Belongs to the GcvT family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.970 |
Jann_1481 | glyA | Jann_1481 | Jann_2991 | FAD dependent oxidoreductase; Belongs to the GcvT family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.478 |
Jann_1596 | Jann_1481 | Jann_1596 | Jann_1481 | Dimethylglycine dehydrogenase; Belongs to the GcvT family. | FAD dependent oxidoreductase; Belongs to the GcvT family. | 0.770 |
Jann_1596 | Jann_2079 | Jann_1596 | Jann_2079 | Dimethylglycine dehydrogenase; Belongs to the GcvT family. | Serine hydroxymethyltransferase. | 0.478 |
Jann_1596 | Jann_2186 | Jann_1596 | Jann_2186 | Dimethylglycine dehydrogenase; Belongs to the GcvT family. | Sarcosine oxidase alpha subunit family; Belongs to the GcvT family. | 0.929 |
Jann_1596 | Jann_2488 | Jann_1596 | Jann_2488 | Dimethylglycine dehydrogenase; Belongs to the GcvT family. | Dimethylglycine dehydrogenase; Belongs to the GcvT family. | 0.761 |
Jann_1596 | Jann_3447 | Jann_1596 | Jann_3447 | Dimethylglycine dehydrogenase; Belongs to the GcvT family. | Sarcosine oxidase alpha subunit family; Belongs to the GcvT family. | 0.809 |
Jann_1596 | gcvH | Jann_1596 | Jann_3621 | Dimethylglycine dehydrogenase; Belongs to the GcvT family. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.838 |
Jann_1596 | gcvP | Jann_1596 | Jann_3622 | Dimethylglycine dehydrogenase; Belongs to the GcvT family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.970 |
Jann_1596 | glyA | Jann_1596 | Jann_2991 | Dimethylglycine dehydrogenase; Belongs to the GcvT family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.478 |
Jann_2079 | Jann_1481 | Jann_2079 | Jann_1481 | Serine hydroxymethyltransferase. | FAD dependent oxidoreductase; Belongs to the GcvT family. | 0.478 |
Jann_2079 | Jann_1596 | Jann_2079 | Jann_1596 | Serine hydroxymethyltransferase. | Dimethylglycine dehydrogenase; Belongs to the GcvT family. | 0.478 |
Jann_2079 | Jann_2186 | Jann_2079 | Jann_2186 | Serine hydroxymethyltransferase. | Sarcosine oxidase alpha subunit family; Belongs to the GcvT family. | 0.957 |
Jann_2079 | Jann_2379 | Jann_2079 | Jann_2379 | Serine hydroxymethyltransferase. | Glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | 0.491 |