node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Jann_2079 | Jann_2663 | Jann_2079 | Jann_2663 | Serine hydroxymethyltransferase. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.652 |
Jann_2079 | fhs | Jann_2079 | Jann_0981 | Serine hydroxymethyltransferase. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.949 |
Jann_2079 | glyA | Jann_2079 | Jann_2991 | Serine hydroxymethyltransferase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.923 |
Jann_2079 | guaB | Jann_2079 | Jann_1982 | Serine hydroxymethyltransferase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.662 |
Jann_2079 | purA | Jann_2079 | Jann_3179 | Serine hydroxymethyltransferase. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.770 |
Jann_2079 | purD | Jann_2079 | Jann_3302 | Serine hydroxymethyltransferase. | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. | 0.707 |
Jann_2079 | purF | Jann_2079 | Jann_1707 | Serine hydroxymethyltransferase. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.782 |
Jann_2079 | purH | Jann_2079 | Jann_4042 | Serine hydroxymethyltransferase. | IMP cyclohydrolase. | 0.979 |
Jann_2079 | purM | Jann_2079 | Jann_1836 | Serine hydroxymethyltransferase. | Phosphoribosylformylglycinamidine cyclo-ligase. | 0.577 |
Jann_2079 | purN | Jann_2079 | Jann_1837 | Serine hydroxymethyltransferase. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.955 |
Jann_2663 | Jann_2079 | Jann_2663 | Jann_2079 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Serine hydroxymethyltransferase. | 0.652 |
Jann_2663 | fhs | Jann_2663 | Jann_0981 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.475 |
Jann_2663 | glyA | Jann_2663 | Jann_2991 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.652 |
Jann_2663 | guaB | Jann_2663 | Jann_1982 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.801 |
Jann_2663 | purA | Jann_2663 | Jann_3179 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.995 |
Jann_2663 | purD | Jann_2663 | Jann_3302 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. | 0.846 |
Jann_2663 | purF | Jann_2663 | Jann_1707 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.870 |
Jann_2663 | purH | Jann_2663 | Jann_4042 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | IMP cyclohydrolase. | 0.984 |
Jann_2663 | purM | Jann_2663 | Jann_1836 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylformylglycinamidine cyclo-ligase. | 0.842 |
Jann_2663 | purN | Jann_2663 | Jann_1837 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.835 |