node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GOX0793 | GOX1636 | GOX0793 | GOX1636 | Low-specificity threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. | 5-Aminolevulinic acid synthase. | 0.907 |
GOX0793 | gcvP | GOX0793 | GOX1097 | Low-specificity threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. | Glycine dehydrogenase [decarboxylating]; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.956 |
GOX0793 | glyA | GOX0793 | GOX2310 | Low-specificity threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. | Serine hydroxymethyl transferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.938 |
GOX1095 | GOX1852 | GOX1095 | GOX1852 | Aminomethyltransferase (Glycine cleavage system T protein). | Glutamate synthase [NADPH] large chain. | 0.903 |
GOX1095 | GOX2022 | GOX1095 | GOX2022 | Aminomethyltransferase (Glycine cleavage system T protein). | Aminomethyltransferase; Belongs to the GcvT family. | 0.775 |
GOX1095 | GOX2292 | GOX1095 | GOX2292 | Aminomethyltransferase (Glycine cleavage system T protein). | Dihydrolipoamide dehydrogenase. | 0.931 |
GOX1095 | gcvH | GOX1095 | GOX1096 | Aminomethyltransferase (Glycine cleavage system T protein). | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.991 |
GOX1095 | gcvP | GOX1095 | GOX1097 | Aminomethyltransferase (Glycine cleavage system T protein). | Glycine dehydrogenase [decarboxylating]; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.998 |
GOX1095 | glyA | GOX1095 | GOX2310 | Aminomethyltransferase (Glycine cleavage system T protein). | Serine hydroxymethyl transferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.990 |
GOX1095 | purQ | GOX1095 | GOX2303 | Aminomethyltransferase (Glycine cleavage system T protein). | Phosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] | 0.800 |
GOX1636 | GOX0793 | GOX1636 | GOX0793 | 5-Aminolevulinic acid synthase. | Low-specificity threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. | 0.907 |
GOX1636 | gcvP | GOX1636 | GOX1097 | 5-Aminolevulinic acid synthase. | Glycine dehydrogenase [decarboxylating]; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.943 |
GOX1636 | glyA | GOX1636 | GOX2310 | 5-Aminolevulinic acid synthase. | Serine hydroxymethyl transferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.911 |
GOX1852 | GOX1095 | GOX1852 | GOX1095 | Glutamate synthase [NADPH] large chain. | Aminomethyltransferase (Glycine cleavage system T protein). | 0.903 |
GOX1852 | GOX2022 | GOX1852 | GOX2022 | Glutamate synthase [NADPH] large chain. | Aminomethyltransferase; Belongs to the GcvT family. | 0.575 |
GOX1852 | GOX2292 | GOX1852 | GOX2292 | Glutamate synthase [NADPH] large chain. | Dihydrolipoamide dehydrogenase. | 0.889 |
GOX1852 | gcvH | GOX1852 | GOX1096 | Glutamate synthase [NADPH] large chain. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.886 |
GOX1852 | gcvP | GOX1852 | GOX1097 | Glutamate synthase [NADPH] large chain. | Glycine dehydrogenase [decarboxylating]; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.899 |
GOX1852 | glyA | GOX1852 | GOX2310 | Glutamate synthase [NADPH] large chain. | Serine hydroxymethyl transferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.463 |
GOX1852 | purQ | GOX1852 | GOX2303 | Glutamate synthase [NADPH] large chain. | Phosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] | 0.900 |