node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
guaA | guaB | DM42_3109 | DM42_3107 | Gmp synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | 0.999 |
guaA | purC | DM42_3109 | DM42_2444 | Gmp synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family | 0.966 |
guaA | purD | DM42_3109 | DM42_2766 | Gmp synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP | Phosphoribosylamine---glycine ligase; Belongs to the GARS family | 0.925 |
guaA | purE | DM42_3109 | DM42_2445 | Gmp synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) | 0.950 |
guaA | purF | DM42_3109 | DM42_4088 | Gmp synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine | 0.952 |
guaA | purH | DM42_3109 | DM42_1151 | Gmp synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP | Bifunctional purine biosynthesis protein PurH; purH: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase | 0.970 |
guaA | purK | DM42_3109 | DM42_2446 | Gmp synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP | Phosphoribosylaminoimidazole carboxylase, atpase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) | 0.851 |
guaA | purL | DM42_3109 | DM42_3186 | Gmp synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP | Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate | 0.995 |
guaA | purM | DM42_3109 | DM42_1077 | Gmp synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP | purM: phosphoribosylformylglycinamidine cyclo-ligase | 0.915 |
guaA | purN | DM42_3109 | DM42_2557 | Gmp synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP | Phosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate | 0.858 |
guaB | guaA | DM42_3107 | DM42_3109 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | Gmp synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP | 0.999 |
guaB | purC | DM42_3107 | DM42_2444 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family | 0.827 |
guaB | purD | DM42_3107 | DM42_2766 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | Phosphoribosylamine---glycine ligase; Belongs to the GARS family | 0.889 |
guaB | purE | DM42_3107 | DM42_2445 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) | 0.899 |
guaB | purF | DM42_3107 | DM42_4088 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine | 0.916 |
guaB | purH | DM42_3107 | DM42_1151 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | Bifunctional purine biosynthesis protein PurH; purH: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase | 0.995 |
guaB | purK | DM42_3107 | DM42_2446 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | Phosphoribosylaminoimidazole carboxylase, atpase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) | 0.826 |
guaB | purL | DM42_3107 | DM42_3186 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate | 0.954 |
guaB | purM | DM42_3107 | DM42_1077 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | purM: phosphoribosylformylglycinamidine cyclo-ligase | 0.931 |
guaB | purN | DM42_3107 | DM42_2557 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | Phosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate | 0.796 |