purM protein (Burkholderia cepacia) - STRING interaction network

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purM

purM- phosphoribosylformylglycinamidine cyclo-ligase (351 aa)

Predicted Functional Partners:

purL

0.999

purF

0.999

purD

0.998

purN

0.997

purH

0.992

purK

0.989

purE

0.959

guaB

0.921

guaA

0.907

purC

0.882

Your Current Organism:

Burkholderia cepacia

NCBI taxonomy Id: 292
Other names: ATCC 25416, B. cepacia, Burkholderia cepacia, Burkholderia cepacia genomovar I, CCUG 12691, CCUG 13226, CFBP 2227, CIP 80.24, DSM 7288, ICMP 5796, IFO 14074, JCM 5964, NBRC 14074, NCCB 76047, NCPPB 2993, NCTC 10743, NRRL B-14810, Pseudomonas cepacia, Pseudomonas kingii, Pseudomonas multivorans, strain 717-ICPB 25, strain Ballard 717

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
guaA	guaB	DM42_3109	DM42_3107	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP	Inosine-5’-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth; Belongs to the IMPDH/GMPR family	0.999
guaA	purC	DM42_3109	DM42_2444	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP	purC- phosphoribosylaminoimidazolesuccinocarboxamide synthase; Belongs to the SAICAR synthetase family	0.965
guaA	purD	DM42_3109	DM42_2766	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP	purD- phosphoribosylamine--glycine ligase; Belongs to the GARS family	0.948
guaA	purE	DM42_3109	DM42_2445	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP	N5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	0.945
guaA	purF	DM42_3109	DM42_4088	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP	Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family	0.947
guaA	purH	DM42_3109	DM42_1151	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP	Bifunctional purine biosynthesis protein PurH; purH- phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	0.966
guaA	purK	DM42_3109	DM42_2446	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP	N5-carboxyaminoimidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	0.837
guaA	purL	DM42_3109	DM42_3186	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP	Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	0.995
guaA	purM	DM42_3109	DM42_1077	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP	purM- phosphoribosylformylglycinamidine cyclo-ligase	0.907
guaA	purN	DM42_3109	DM42_2557	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP	Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	0.847
guaB	guaA	DM42_3107	DM42_3109	Inosine-5’-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth; Belongs to the IMPDH/GMPR family	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP	0.999
guaB	purC	DM42_3107	DM42_2444	Inosine-5’-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth; Belongs to the IMPDH/GMPR family	purC- phosphoribosylaminoimidazolesuccinocarboxamide synthase; Belongs to the SAICAR synthetase family	0.894
guaB	purD	DM42_3107	DM42_2766	Inosine-5’-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth; Belongs to the IMPDH/GMPR family	purD- phosphoribosylamine--glycine ligase; Belongs to the GARS family	0.866
guaB	purE	DM42_3107	DM42_2445	Inosine-5’-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth; Belongs to the IMPDH/GMPR family	N5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	0.886
guaB	purF	DM42_3107	DM42_4088	Inosine-5’-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth; Belongs to the IMPDH/GMPR family	Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family	0.919
guaB	purH	DM42_3107	DM42_1151	Inosine-5’-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth; Belongs to the IMPDH/GMPR family	Bifunctional purine biosynthesis protein PurH; purH- phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	0.994
guaB	purK	DM42_3107	DM42_2446	Inosine-5’-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth; Belongs to the IMPDH/GMPR family	N5-carboxyaminoimidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	0.805
guaB	purL	DM42_3107	DM42_3186	Inosine-5’-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth; Belongs to the IMPDH/GMPR family	Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	0.952
guaB	purM	DM42_3107	DM42_1077	Inosine-5’-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth; Belongs to the IMPDH/GMPR family	purM- phosphoribosylformylglycinamidine cyclo-ligase	0.921
guaB	purN	DM42_3107	DM42_2557	Inosine-5’-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth; Belongs to the IMPDH/GMPR family	Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	0.765

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