WL94_35110 protein (Burkholderia cepacia) - STRING interaction network

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WL94_35110

Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (1001 aa)

Predicted Functional Partners:

WI67_02740

0.995

tmk

0.940

ndk

0.923

adk

0.918

mesh1

0.918

cmk

0.917

pyk

0.915

pnp

0.914

gmk

0.912

WI67_04795

0.909

Your Current Organism:

Burkholderia cepacia

NCBI taxonomy Id: 292
Other names: ATCC 25416, B. cepacia, Burkholderia cepacia, Burkholderia cepacia genomovar I, CCUG 12691, CCUG 13226, CFBP 2227, CIP 80.24, DSM 7288, ICMP 5796, IFO 14074, JCM 5964, NBRC 14074, NCCB 76047, NCPPB 2993, NCTC 10743, NRRL B-14810, Pseudomonas cepacia, Pseudomonas kingii, Pseudomonas multivorans, strain 717-ICPB 25, strain Ballard 717

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
WI67_02740	WI67_04795	DM42_1244	DM42_835	Ribonucleoside-diphosphate reductase subunit beta; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family	Bifunctional (P)ppGpp synthetase/guanosine-3’,5’-bis(Diphosphate) 3’-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3’-diphosphate 5-’ diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	0.904
WI67_02740	WL94_35110	DM42_1244	DM42_1245	Ribonucleoside-diphosphate reductase subunit beta; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	0.995
WI67_02740	adk	DM42_1244	DM42_2520	Ribonucleoside-diphosphate reductase subunit beta; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family	0.912
WI67_02740	cmk	DM42_1244	DM42_781	Ribonucleoside-diphosphate reductase subunit beta; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family	Cmk- cytidylate kinase; Belongs to the cytidylate kinase family. Type 1 subfamily	0.922
WI67_02740	gmk	DM42_1244	DM42_837	Ribonucleoside-diphosphate reductase subunit beta; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP	0.919
WI67_02740	mesh1	DM42_1244	DM42_7377	Ribonucleoside-diphosphate reductase subunit beta; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family	annotation not available	0.914
WI67_02740	ndk	DM42_1244	DM42_3285	Ribonucleoside-diphosphate reductase subunit beta; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	0.918
WI67_02740	pnp	DM42_1244	DM42_2808	Ribonucleoside-diphosphate reductase subunit beta; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family	Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3’- to 5’-direction	0.905
WI67_02740	pyk	DM42_1244	DM42_2442	Ribonucleoside-diphosphate reductase subunit beta; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family	Pyruv_kin- pyruvate kinase; Belongs to the pyruvate kinase family	0.905
WI67_02740	tmk	DM42_1244	DM42_3208	Ribonucleoside-diphosphate reductase subunit beta; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family	Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	0.920
WI67_04795	WI67_02740	DM42_835	DM42_1244	Bifunctional (P)ppGpp synthetase/guanosine-3’,5’-bis(Diphosphate) 3’-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3’-diphosphate 5-’ diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	Ribonucleoside-diphosphate reductase subunit beta; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family	0.904
WI67_04795	WL94_35110	DM42_835	DM42_1245	Bifunctional (P)ppGpp synthetase/guanosine-3’,5’-bis(Diphosphate) 3’-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3’-diphosphate 5-’ diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	0.909
WI67_04795	gmk	DM42_835	DM42_837	Bifunctional (P)ppGpp synthetase/guanosine-3’,5’-bis(Diphosphate) 3’-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3’-diphosphate 5-’ diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP	0.981
WI67_04795	mesh1	DM42_835	DM42_7377	Bifunctional (P)ppGpp synthetase/guanosine-3’,5’-bis(Diphosphate) 3’-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3’-diphosphate 5-’ diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	annotation not available	0.821
WI67_04795	ndk	DM42_835	DM42_3285	Bifunctional (P)ppGpp synthetase/guanosine-3’,5’-bis(Diphosphate) 3’-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3’-diphosphate 5-’ diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	0.903
WI67_04795	pnp	DM42_835	DM42_2808	Bifunctional (P)ppGpp synthetase/guanosine-3’,5’-bis(Diphosphate) 3’-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3’-diphosphate 5-’ diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3’- to 5’-direction	0.906
WI67_04795	pyk	DM42_835	DM42_2442	Bifunctional (P)ppGpp synthetase/guanosine-3’,5’-bis(Diphosphate) 3’-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3’-diphosphate 5-’ diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	Pyruv_kin- pyruvate kinase; Belongs to the pyruvate kinase family	0.903
WL94_35110	WI67_02740	DM42_1245	DM42_1244	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	Ribonucleoside-diphosphate reductase subunit beta; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family	0.995
WL94_35110	WI67_04795	DM42_1245	DM42_835	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	Bifunctional (P)ppGpp synthetase/guanosine-3’,5’-bis(Diphosphate) 3’-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3’-diphosphate 5-’ diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	0.909
WL94_35110	adk	DM42_1245	DM42_2520	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family	0.918

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