node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Prs | guaA | DM42_4900 | DM42_3109 | Ribose-phosphate pyrophosphokinase; ribP_PPkin: ribose-phosphate diphosphokinase family protein | Gmp synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP | 0.890 |
Prs | polA | DM42_4900 | DM42_4183 | Ribose-phosphate pyrophosphokinase; ribP_PPkin: ribose-phosphate diphosphokinase family protein | In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity | 0.658 |
Prs | prs | DM42_4900 | DM42_2267 | Ribose-phosphate pyrophosphokinase; ribP_PPkin: ribose-phosphate diphosphokinase family protein | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P) | 0.837 |
Prs | purL | DM42_4900 | DM42_3186 | Ribose-phosphate pyrophosphokinase; ribP_PPkin: ribose-phosphate diphosphokinase family protein | Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate | 0.503 |
Prs | pyrE | DM42_4900 | DM42_1512 | Ribose-phosphate pyrophosphokinase; ribP_PPkin: ribose-phosphate diphosphokinase family protein | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) | 0.856 |
carA | carB | DM42_431 | DM42_429 | Carbamoyl-phosphate synthase small subunit; Belongs to the CarA family | Carbamoyl-phosphate synthase large subunit; Belongs to the CarB family | 0.999 |
carA | guaA | DM42_431 | DM42_3109 | Carbamoyl-phosphate synthase small subunit; Belongs to the CarA family | Gmp synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP | 0.712 |
carA | purL | DM42_431 | DM42_3186 | Carbamoyl-phosphate synthase small subunit; Belongs to the CarA family | Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate | 0.703 |
carA | pyrD | DM42_431 | DM42_139 | Carbamoyl-phosphate synthase small subunit; Belongs to the CarA family | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor | 0.675 |
carA | pyrE | DM42_431 | DM42_1512 | Carbamoyl-phosphate synthase small subunit; Belongs to the CarA family | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) | 0.987 |
carA | pyrF | DM42_431 | DM42_1216 | Carbamoyl-phosphate synthase small subunit; Belongs to the CarA family | Orotidine-5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily | 0.999 |
carB | carA | DM42_429 | DM42_431 | Carbamoyl-phosphate synthase large subunit; Belongs to the CarB family | Carbamoyl-phosphate synthase small subunit; Belongs to the CarA family | 0.999 |
carB | guaA | DM42_429 | DM42_3109 | Carbamoyl-phosphate synthase large subunit; Belongs to the CarB family | Gmp synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP | 0.972 |
carB | polA | DM42_429 | DM42_4183 | Carbamoyl-phosphate synthase large subunit; Belongs to the CarB family | In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity | 0.664 |
carB | purL | DM42_429 | DM42_3186 | Carbamoyl-phosphate synthase large subunit; Belongs to the CarB family | Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate | 0.952 |
carB | pyrD | DM42_429 | DM42_139 | Carbamoyl-phosphate synthase large subunit; Belongs to the CarB family | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor | 0.814 |
carB | pyrE | DM42_429 | DM42_1512 | Carbamoyl-phosphate synthase large subunit; Belongs to the CarB family | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) | 0.960 |
carB | pyrF | DM42_429 | DM42_1216 | Carbamoyl-phosphate synthase large subunit; Belongs to the CarB family | Orotidine-5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily | 0.999 |
guaA | Prs | DM42_3109 | DM42_4900 | Gmp synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP | Ribose-phosphate pyrophosphokinase; ribP_PPkin: ribose-phosphate diphosphokinase family protein | 0.890 |
guaA | carA | DM42_3109 | DM42_431 | Gmp synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP | Carbamoyl-phosphate synthase small subunit; Belongs to the CarA family | 0.712 |