Co-purification, co-crystallization, Yeast2Hybrid, Genetic Interactions, etc ... as imported from primary sources.
Genes that are sometimes fused into single open reading frames.
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
from curated databases
6-carboxy-5,6,7,8-tetrahydropterin synthase; queuosine_QueD- queuosine biosynthesis protein QueD (150 aa)
Predicted Functional Partners:
7-carboxy-7-deazaguanine synthase; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds (210 aa)
annotation not available (243 aa)
folE- GTP cyclohydrolase I (211 aa)
GTP cyclohydrolase FolE2; Converts GTP to 7,8-dihydroneopterin triphosphate (269 aa)
annotation not available (164 aa)
annotation not available (306 aa)
annotation not available (192 aa)
annotation not available (477 aa)
annotation not available (463 aa)
NADPH-dependent 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (276 aa)