node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DM42_4849 | WL94_22650 | DM42_4849 | DM42_1960 | ftsH_fam: ATP-dependent metallopeptidase HflB family protein | annotation not available | 0.556 |
DM42_4849 | clpP | DM42_4849 | DM42_3175 | ftsH_fam: ATP-dependent metallopeptidase HflB family protein | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins; Belongs to the peptidase S14 family | 0.449 |
DM42_4849 | grpE | DM42_4849 | DM42_1088 | ftsH_fam: ATP-dependent metallopeptidase HflB family protein | Protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- dependent [...] | 0.435 |
DM42_4849 | polA | DM42_4849 | DM42_4183 | ftsH_fam: ATP-dependent metallopeptidase HflB family protein | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity | 0.625 |
WI67_24720 | WL94_22650 | DM42_6387 | DM42_1960 | ATP-dependent zinc metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family | annotation not available | 0.554 |
WI67_24720 | clpP | DM42_6387 | DM42_3175 | ATP-dependent zinc metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins; Belongs to the peptidase S14 family | 0.441 |
WI67_24720 | grpE | DM42_6387 | DM42_1088 | ATP-dependent zinc metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family | Protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- dependent [...] | 0.435 |
WI67_24720 | polA | DM42_6387 | DM42_4183 | ATP-dependent zinc metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity | 0.625 |
WL94_22650 | DM42_4849 | DM42_1960 | DM42_4849 | annotation not available | ftsH_fam: ATP-dependent metallopeptidase HflB family protein | 0.556 |
WL94_22650 | WI67_24720 | DM42_1960 | DM42_6387 | annotation not available | ATP-dependent zinc metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family | 0.554 |
WL94_22650 | clpP | DM42_1960 | DM42_3175 | annotation not available | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins; Belongs to the peptidase S14 family | 0.597 |
WL94_22650 | clpX | DM42_1960 | DM42_3176 | annotation not available | ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP | 0.745 |
WL94_22650 | grpE | DM42_1960 | DM42_1088 | annotation not available | Protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- dependent [...] | 0.646 |
WL94_22650 | hslU | DM42_1960 | DM42_1920 | annotation not available | ATP-dependent protease ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis | 0.744 |
WL94_22650 | hslV | DM42_1960 | DM42_1921 | annotation not available | ATP-dependent protease subunit HslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery | 0.702 |
WL94_22650 | htpG | DM42_1960 | DM42_2714 | annotation not available | Chaperone protein HtpG; Molecular chaperone. Has ATPase activity | 0.654 |
WL94_22650 | polA | DM42_1960 | DM42_4183 | annotation not available | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity | 0.601 |
WL94_22650 | ribD | DM42_1960 | DM42_881 | annotation not available | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate; In the C-terminal section; belongs to the HTP reductase family | 0.595 |
clpP | DM42_4849 | DM42_3175 | DM42_4849 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins; Belongs to the peptidase S14 family | ftsH_fam: ATP-dependent metallopeptidase HflB family protein | 0.449 |
clpP | WI67_24720 | DM42_3175 | DM42_6387 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins; Belongs to the peptidase S14 family | ATP-dependent zinc metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family | 0.441 |