WL94_13975 protein (Burkholderia cepacia) - STRING interaction network

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WL94_13975

2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily (548 aa)

Predicted Functional Partners:

leuC

0.987

WI67_22900

0.970

WL94_04345

0.964

leuD

0.950

WL94_05875

0.949

DM42_4992

0.949

ilvE

0.931

WL94_39140

0.917

acoC

0.913

WL94_31655

0.908

Your Current Organism:

Burkholderia cepacia

NCBI taxonomy Id: 292
Other names: ATCC 25416, B. cepacia, Burkholderia cepacia, Burkholderia cepacia genomovar I, CCUG 12691, CCUG 13226, CFBP 2227, CIP 80.24, DSM 7288, ICMP 5796, IFO 14074, JCM 5964, NBRC 14074, NCCB 76047, NCPPB 2993, NCTC 10743, NRRL B-14810, Pseudomonas cepacia, Pseudomonas kingii, Pseudomonas multivorans, strain 717-ICPB 25, strain Ballard 717

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DM42_4992	WL94_05875	DM42_4992	DM42_6344	ac_ald_DH_ac- acetaldehyde dehydrogenase	Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds	0.802
DM42_4992	WL94_13975	DM42_4992	DM42_2257	ac_ald_DH_ac- acetaldehyde dehydrogenase	2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily	0.949
DM42_4992	acoC	DM42_4992	DM42_3263	ac_ald_DH_ac- acetaldehyde dehydrogenase	annotation not available	0.906
WI67_22900	WL94_04345	DM42_3831	DM42_2606	ilvD- dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family	ilvD- dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family	0.809
WI67_22900	WL94_13975	DM42_3831	DM42_2257	ilvD- dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family	2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily	0.970
WI67_22900	WL94_31655	DM42_3831	DM42_3245	ilvD- dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family	annotation not available	0.905
WI67_22900	WL94_39140	DM42_3831	DM42_5889	ilvD- dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family	annotation not available	0.936
WI67_22900	ilvE	DM42_3831	DM42_2438	ilvD- dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family	Branched-chain-amino-acid aminotransferase; Acts on leucine, isoleucine and valine; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	0.950
WI67_22900	leuC	DM42_3831	DM42_4103	ilvD- dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family	3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate; Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily	0.839
WI67_22900	leuD	DM42_3831	DM42_4102	ilvD- dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family	3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate; Belongs to the LeuD family. LeuD type 1 subfamily	0.755
WL94_04345	WI67_22900	DM42_2606	DM42_3831	ilvD- dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family	ilvD- dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family	0.809
WL94_04345	WL94_13975	DM42_2606	DM42_2257	ilvD- dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family	2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily	0.964
WL94_04345	WL94_31655	DM42_2606	DM42_3245	ilvD- dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family	annotation not available	0.905
WL94_04345	WL94_39140	DM42_2606	DM42_5889	ilvD- dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family	annotation not available	0.936
WL94_04345	ilvE	DM42_2606	DM42_2438	ilvD- dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family	Branched-chain-amino-acid aminotransferase; Acts on leucine, isoleucine and valine; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	0.950
WL94_04345	leuC	DM42_2606	DM42_4103	ilvD- dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family	3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate; Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily	0.839
WL94_04345	leuD	DM42_2606	DM42_4102	ilvD- dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family	3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate; Belongs to the LeuD family. LeuD type 1 subfamily	0.701
WL94_05875	DM42_4992	DM42_6344	DM42_4992	Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds	ac_ald_DH_ac- acetaldehyde dehydrogenase	0.802
WL94_05875	WL94_13975	DM42_6344	DM42_2257	Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds	2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily	0.949
WL94_05875	acoC	DM42_6344	DM42_3263	Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds	annotation not available	0.906

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