node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DM42_3510 | kynA | DM42_3510 | DM42_2490 | annotation not available | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety | 0.935 |
DM42_3510 | kynB | DM42_3510 | DM42_2492 | annotation not available | Arylformamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation | 0.800 |
DM42_3510 | kynU | DM42_3510 | DM42_2491 | annotation not available | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively | 0.935 |
DM42_3566 | DM42_5471 | DM42_3566 | DM42_5471 | annotation not available | annotation not available | 0.837 |
DM42_3566 | hmgA | DM42_3566 | DM42_1009 | annotation not available | Homogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate | 0.984 |
DM42_3566 | hppD | DM42_3566 | DM42_1508 | annotation not available | 4HPPD: 4-hydroxyphenylpyruvate dioxygenase | 0.811 |
DM42_3566 | kynA | DM42_3566 | DM42_2490 | annotation not available | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety | 0.419 |
DM42_5471 | DM42_3566 | DM42_5471 | DM42_3566 | annotation not available | annotation not available | 0.837 |
DM42_5471 | hmgA | DM42_5471 | DM42_1009 | annotation not available | Homogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate | 0.979 |
DM42_5471 | hppD | DM42_5471 | DM42_1508 | annotation not available | 4HPPD: 4-hydroxyphenylpyruvate dioxygenase | 0.832 |
DM42_5471 | kynA | DM42_5471 | DM42_2490 | annotation not available | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety | 0.413 |
hmgA | DM42_3566 | DM42_1009 | DM42_3566 | Homogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate | annotation not available | 0.984 |
hmgA | DM42_5471 | DM42_1009 | DM42_5471 | Homogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate | annotation not available | 0.979 |
hmgA | hppD | DM42_1009 | DM42_1508 | Homogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate | 4HPPD: 4-hydroxyphenylpyruvate dioxygenase | 0.994 |
hmgA | kynA | DM42_1009 | DM42_2490 | Homogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety | 0.454 |
hmgA | kynU | DM42_1009 | DM42_2491 | Homogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively | 0.598 |
hppD | DM42_3566 | DM42_1508 | DM42_3566 | 4HPPD: 4-hydroxyphenylpyruvate dioxygenase | annotation not available | 0.811 |
hppD | DM42_5471 | DM42_1508 | DM42_5471 | 4HPPD: 4-hydroxyphenylpyruvate dioxygenase | annotation not available | 0.832 |
hppD | hmgA | DM42_1508 | DM42_1009 | 4HPPD: 4-hydroxyphenylpyruvate dioxygenase | Homogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate | 0.994 |
hppD | kynA | DM42_1508 | DM42_2490 | 4HPPD: 4-hydroxyphenylpyruvate dioxygenase | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety | 0.426 |