node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DM42_1766 | katE | DM42_1766 | DM42_7100 | Catalase family protein; Has an organic peroxide-dependent peroxidase activity | Catalase family protein; Serves to protect cells from the toxic effects of hydrogen peroxide | 0.477 |
DM42_1766 | kynU | DM42_1766 | DM42_2491 | Catalase family protein; Has an organic peroxide-dependent peroxidase activity | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively | 0.904 |
DM42_3510 | kynA | DM42_3510 | DM42_2490 | annotation not available | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety | 0.935 |
DM42_3510 | kynB | DM42_3510 | DM42_2492 | annotation not available | Arylformamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation | 0.800 |
DM42_3510 | kynU | DM42_3510 | DM42_2491 | annotation not available | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively | 0.935 |
DM42_4155 | kynU | DM42_4155 | DM42_2491 | annotation not available | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively | 0.904 |
DM42_6472 | katE | DM42_6472 | DM42_7100 | annotation not available | Catalase family protein; Serves to protect cells from the toxic effects of hydrogen peroxide | 0.489 |
DM42_6472 | kynU | DM42_6472 | DM42_2491 | annotation not available | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively | 0.904 |
hmgA | kynA | DM42_1009 | DM42_2490 | Homogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety | 0.454 |
hmgA | kynU | DM42_1009 | DM42_2491 | Homogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively | 0.598 |
katE | DM42_1766 | DM42_7100 | DM42_1766 | Catalase family protein; Serves to protect cells from the toxic effects of hydrogen peroxide | Catalase family protein; Has an organic peroxide-dependent peroxidase activity | 0.477 |
katE | DM42_6472 | DM42_7100 | DM42_6472 | Catalase family protein; Serves to protect cells from the toxic effects of hydrogen peroxide | annotation not available | 0.489 |
katE | katG | DM42_7100 | DM42_1113 | Catalase family protein; Serves to protect cells from the toxic effects of hydrogen peroxide | Catalase/peroxidase hpi; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity | 0.805 |
katE | kynU | DM42_7100 | DM42_2491 | Catalase family protein; Serves to protect cells from the toxic effects of hydrogen peroxide | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively | 0.904 |
katG | katE | DM42_1113 | DM42_7100 | Catalase/peroxidase hpi; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity | Catalase family protein; Serves to protect cells from the toxic effects of hydrogen peroxide | 0.805 |
katG | kynU | DM42_1113 | DM42_2491 | Catalase/peroxidase hpi; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively | 0.900 |
kynA | DM42_3510 | DM42_2490 | DM42_3510 | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety | annotation not available | 0.935 |
kynA | hmgA | DM42_2490 | DM42_1009 | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety | Homogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate | 0.454 |
kynA | kynB | DM42_2490 | DM42_2492 | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety | Arylformamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation | 0.996 |
kynA | kynU | DM42_2490 | DM42_2491 | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively | 0.997 |