node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DM42_2519 | mviN | DM42_2519 | DM42_2518 | annotation not available | Putative peptidoglycan lipid ii flippase; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane | 0.891 |
cysS | mviN | DM42_3009 | DM42_2518 | Cysteinyl-trna synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family | Putative peptidoglycan lipid ii flippase; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane | 0.727 |
cysS | secA | DM42_3009 | DM42_1271 | Cysteinyl-trna synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family | Preprotein translocase, seca subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane | 0.479 |
dnaB | ftsW | DM42_3231 | DM42_1281 | Replicative dna helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins | Cell division protein ftsw; Peptidoglycan polymerase that is essential for cell division | 0.601 |
dnaB | mrdB | DM42_3231 | DM42_1897 | Replicative dna helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins | Rod shape determining protein roda; Peptidoglycan polymerase that is essential for cell wall elongation | 0.566 |
dnaB | murG | DM42_3231 | DM42_1280 | Replicative dna helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins | Udp-n-acetylglucosamine--n-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol n-acetylglucosamine transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) | 0.517 |
dnaB | mviN | DM42_3231 | DM42_2518 | Replicative dna helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins | Putative peptidoglycan lipid ii flippase; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane | 0.811 |
dnaB | ribF | DM42_3231 | DM42_2556 | Replicative dna helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins | Riboflavin kinase / fmn adenylyltransferase; Belongs to the ribF family | 0.641 |
dnaB | secA | DM42_3231 | DM42_1271 | Replicative dna helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins | Preprotein translocase, seca subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane | 0.600 |
dxs | mviN | DM42_4176 | DM42_2518 | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP) | Putative peptidoglycan lipid ii flippase; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane | 0.696 |
dxs | ribF | DM42_4176 | DM42_2556 | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP) | Riboflavin kinase / fmn adenylyltransferase; Belongs to the ribF family | 0.692 |
ftsW | dnaB | DM42_1281 | DM42_3231 | Cell division protein ftsw; Peptidoglycan polymerase that is essential for cell division | Replicative dna helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins | 0.601 |
ftsW | glmU | DM42_1281 | DM42_2028 | Cell division protein ftsw; Peptidoglycan polymerase that is essential for cell division | Bifunctional udp-n-acetylglucosamine pyrophosphorylase / glucosamine-1-phosphate n-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain | 0.477 |
ftsW | mrdB | DM42_1281 | DM42_1897 | Cell division protein ftsw; Peptidoglycan polymerase that is essential for cell division | Rod shape determining protein roda; Peptidoglycan polymerase that is essential for cell wall elongation | 0.473 |
ftsW | murG | DM42_1281 | DM42_1280 | Cell division protein ftsw; Peptidoglycan polymerase that is essential for cell division | Udp-n-acetylglucosamine--n-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol n-acetylglucosamine transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) | 0.991 |
ftsW | mviN | DM42_1281 | DM42_2518 | Cell division protein ftsw; Peptidoglycan polymerase that is essential for cell division | Putative peptidoglycan lipid ii flippase; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane | 0.768 |
ftsW | secA | DM42_1281 | DM42_1271 | Cell division protein ftsw; Peptidoglycan polymerase that is essential for cell division | Preprotein translocase, seca subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane | 0.442 |
glmU | ftsW | DM42_2028 | DM42_1281 | Bifunctional udp-n-acetylglucosamine pyrophosphorylase / glucosamine-1-phosphate n-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain | Cell division protein ftsw; Peptidoglycan polymerase that is essential for cell division | 0.477 |
glmU | mrdB | DM42_2028 | DM42_1897 | Bifunctional udp-n-acetylglucosamine pyrophosphorylase / glucosamine-1-phosphate n-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain | Rod shape determining protein roda; Peptidoglycan polymerase that is essential for cell wall elongation | 0.432 |
glmU | murG | DM42_2028 | DM42_1280 | Bifunctional udp-n-acetylglucosamine pyrophosphorylase / glucosamine-1-phosphate n-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain | Udp-n-acetylglucosamine--n-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol n-acetylglucosamine transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) | 0.693 |