valS protein (Burkholderia cepacia) - STRING interaction network

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valS

Valine--tRNA ligase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a "posttransfer" editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily (955 aa)

Predicted Functional Partners:

ileS

0.905

leuS

0.884

pheS

0.882

thrS

0.874

infB

0.871

hisS

0.863

metG

0.862

cysS

0.858

argS

0.856

guaA

0.850

Your Current Organism:

Burkholderia cepacia

NCBI taxonomy Id: 292
Other names: ATCC 25416, B. cepacia, Burkholderia cepacia, Burkholderia cepacia genomovar I, CCUG 12691, CCUG 13226, CFBP 2227, CIP 80.24, DSM 7288, ICMP 5796, IFO 14074, JCM 5964, NBRC 14074, NCCB 76047, NCPPB 2993, NCTC 10743, NRRL B-14810, Pseudomonas cepacia, Pseudomonas kingii, Pseudomonas multivorans, strain 717-ICPB 25, strain Ballard 717

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
argS	cysS	DM42_2152	DM42_3009	argS- arginine--tRNA ligase	cysS- cysteine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family	0.771
argS	guaA	DM42_2152	DM42_3109	argS- arginine--tRNA ligase	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP	0.802
argS	hisS	DM42_2152	DM42_3289	argS- arginine--tRNA ligase	hisS- histidine--tRNA ligase	0.659
argS	ileS	DM42_2152	DM42_2555	argS- arginine--tRNA ligase	Isoleucine--tRNA ligase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as ’pretransfer’ editing and involves the hydrolysis of activated Val-AMP. The other activity is designated ’posttransfer’ editing and involves deacylation of mischarged Val-tRNA(Ile)	0.937
argS	infB	DM42_2152	DM42_199	argS- arginine--tRNA ligase	Translation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	0.651
argS	leuS	DM42_2152	DM42_1189	argS- arginine--tRNA ligase	leuS_bact- leucine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family	0.938
argS	metG	DM42_2152	DM42_2632	argS- arginine--tRNA ligase	Methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily	0.907
argS	pheS	DM42_2152	DM42_221	argS- arginine--tRNA ligase	pheS- phenylalanine--tRNA ligase, alpha subunit; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	0.771
argS	thrS	DM42_2152	DM42_225	argS- arginine--tRNA ligase	Threonine--tRNA ligase; Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction- L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	0.812
argS	valS	DM42_2152	DM42_259	argS- arginine--tRNA ligase	Valine--tRNA ligase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a "posttransfer" editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily	0.856
cysS	argS	DM42_3009	DM42_2152	cysS- cysteine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family	argS- arginine--tRNA ligase	0.771
cysS	guaA	DM42_3009	DM42_3109	cysS- cysteine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP	0.784
cysS	hisS	DM42_3009	DM42_3289	cysS- cysteine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family	hisS- histidine--tRNA ligase	0.743
cysS	ileS	DM42_3009	DM42_2555	cysS- cysteine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family	Isoleucine--tRNA ligase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as ’pretransfer’ editing and involves the hydrolysis of activated Val-AMP. The other activity is designated ’posttransfer’ editing and involves deacylation of mischarged Val-tRNA(Ile)	0.920
cysS	infB	DM42_3009	DM42_199	cysS- cysteine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family	Translation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	0.733
cysS	leuS	DM42_3009	DM42_1189	cysS- cysteine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family	leuS_bact- leucine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family	0.913
cysS	metG	DM42_3009	DM42_2632	cysS- cysteine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family	Methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily	0.858
cysS	pheS	DM42_3009	DM42_221	cysS- cysteine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family	pheS- phenylalanine--tRNA ligase, alpha subunit; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	0.596
cysS	thrS	DM42_3009	DM42_225	cysS- cysteine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family	Threonine--tRNA ligase; Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction- L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	0.834
cysS	valS	DM42_3009	DM42_259	cysS- cysteine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family	Valine--tRNA ligase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a "posttransfer" editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily	0.858

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