STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cobAUroporphyrinogen-iii c-methyltransferase; Belongs to the precorrin methyltransferase family (249 aa)    
Predicted Functional Partners:
hemDX
annotation not available
 
 0.970
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
  
 
 0.926
cobI
Precorrin-2/cobalt-factor-2 C20-methyltransferase; Methylates precorrin-2 at the C-20 position to produce precorrin-3A
 
  
0.920
hemC
Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps
  
 0.889
CysC
Bifunctional enzyme cysn/cysc; Catalyzes the synthesis of activated sulfate
 
  
 0.834
CobA
cobA_cysG_Cterm: uroporphyrinogen-III C-methyltransferase
  
  
 
0.834
cysH
Adenylylsulfate reductase, thioredoxin dependent family protein; Reduction of activated sulfate into sulfite. Uses adenylyl sulfate as substrate and thioredoxin as electron donor
 
  
 0.833
DM42_6268
cobA_cysG_Cterm: uroporphyrinogen-III C-methyltransferase
  
  
 
0.826
cysN
Sulfate adenylyltransferase, large subunit; May be the GTPase, regulating ATP sulfurylase activity
 
  
 0.795
cbiT
cbiT: precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit
  
  
 0.791
Your Current Organism:
Burkholderia cepacia
NCBI taxonomy Id: 292
Other names: ATCC 25416, B. cepacia, Burkholderia cepacia genomovar I, CCUG 12691, CCUG 13226, CFBP 2227, CIP 80.24, DSM 7288, ICMP 5796, IFO 14074, JCM 5964, NBRC 14074, NCCB 76047, NCPPB 2993, NCTC 10743, NRRL B-14810, Pseudomonas cepacia, Pseudomonas kingii, Pseudomonas multivorans, strain 717-ICPB 25, strain Ballard 717
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