STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemDXannotation not available (656 aa)    
Predicted Functional Partners:
hemC
Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps
 
 0.999
DM42_2650
annotation not available
 
 
 0.987
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
  
 
 0.981
cobA
Uroporphyrinogen-iii c-methyltransferase; Belongs to the precorrin methyltransferase family
 
 0.970
CobA
cobA_cysG_Cterm: uroporphyrinogen-III C-methyltransferase
 
 
 0.966
DM42_6268
cobA_cysG_Cterm: uroporphyrinogen-III C-methyltransferase
 
 
 0.966
cobI
Precorrin-2/cobalt-factor-2 C20-methyltransferase; Methylates precorrin-2 at the C-20 position to produce precorrin-3A
    
  0.922
hemB
Delta-aminolevulinic acid dehydratase family protein; Belongs to the ALAD family
  
 
 0.862
hemA
Glutamyl-trna reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA)
 
 
 0.860
hemF
annotation not available
  
  
 0.814
Your Current Organism:
Burkholderia cepacia
NCBI taxonomy Id: 292
Other names: ATCC 25416, B. cepacia, Burkholderia cepacia genomovar I, CCUG 12691, CCUG 13226, CFBP 2227, CIP 80.24, DSM 7288, ICMP 5796, IFO 14074, JCM 5964, NBRC 14074, NCCB 76047, NCPPB 2993, NCTC 10743, NRRL B-14810, Pseudomonas cepacia, Pseudomonas kingii, Pseudomonas multivorans, strain 717-ICPB 25, strain Ballard 717
Server load: low (4%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.